Figure 1

Kidney damage, endothelial Angiopoietin/Tie2 system, and flow responsive gene expression in renal biopsies from sepsis patients compared to healthy kidney part from patients with renal cell carcinoma. Renal neutrophil gelatinase-associated lipocalin (NGAL) (A) (P=0,0004), Tyrosine-protein kinase receptor TIE-2 (Tie2) (B) (P=0,0004), cluster of differentiation 31 (CD31) (C) (NS), Angiopoietin 1 (Ang1) (P=0,0003) (D), Angiopoietin 2 (Ang2) (E) (P=0,005), Angiopoietin 1/Angiopoietin 2 ratio (F) (P=0,0467), Kruppel-like factor 2 (KLF2) (G) (P=0,0003) mRNA gene expression in renal biopsies from sepsis patients (n=11) compared to healthy kidney part from patients with renal cell carcinoma (n=8). Each dot represents the mean of two biopsies per patient. Tie2 gene expression levels in renal biopsies correlates with the mRNA levels of KLF2 in both control biopsies (R2= 0,91; P=0,0002) (H) as well as in kidney biopsies from sepsis patients (R2= 0,70; P<0,0001) (I). Low expression of Tie2 is associated with low levels of KLF2 gene expression. Lines denote best fit, with the dashed lines representing the 95% confidence interval for best fit. ns, Not significant. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.