Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study

Table 2 Linear and piecewise linear multiple logistic regression models with 28-day mortality as the dependent variable

	Linear model		Piecewise linear model
	Odds ratio v	P value	Segment	Odds ratio (95% CI)	P value
Fibrinogen (g/l)^a	0.46	< 0.001	Lower	0.08	< 0.001
	0.46			(0.03, 0.20)
	(0.31, 0.67)			(0.03, 0.20)
			Upper	1.77	0.076
			Upper	(0.94, 3.32)	0.076
Injury severity score^b	1.03	0.008	Lower	1.18	< 0.001
	1.03			(1.10, 1.27)
	(1.01, 1.05)			(1.10, 1.27)
			Upper	0.93	0.001
			Upper	(0.89, 0.97)	0.001
Age (years)	1.05	< 0.001		1.04	< 0.001
Age (years)	(1.03, 1.06)	< 0.001		(1.02, 1.06)	< 0.001
Time from injury (minutes)	0.99	0.166		0.99	0.018
Time from injury (minutes)	(0.99, 1.00)	0.166		(0.98, 1.00)	0.018
Mechanism of injury (penetrating)	0.73	0.546		0.33	0.06
Mechanism of injury (penetrating)	(0.25, 1.90)	0.546		(0.10, 1.05)	0.06
Base excess (mEq/l)	0.90	< 0.001		0.92	0.002
Base excess (mEq/l)	(0.85, 0.95)	< 0.001		(0.87, 0.97)	0.002
International normalized ratio	3.21	0.012		1.65	0.29
International normalized ratio	(1.33, 8.53)	0.012		(0.65, 4.18)	0.29
Platelet count (10⁹/l)	1.00	0.61		1.00	0.92
Platelet count (10⁹/l)	(1.00, 1.00)	0.61		(1.00, 1.00)	0.92
Gender (male)	0.45	0.006		0.33	0.001
Gender (male)	(0.26, 0.81)	0.006		(0.18, 0.62)	0.001

^aBreakpoint for fibrinogen is 2.29 g/l (95% confidence interval (CI): 1.93, 2.64). ^bBreakpoint for Injury Severity Score is 25.7 (95% CI: 21.8, 29.7).

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