Figure 4

Leak state O ₂ consumption, i. e., the respiratory activity necessary to compensate for the proton leakage, slipping, and cation-exchange along the inner mitochondrial membrane, as a fraction of the maximal O ₂ consumption in the uncoupled state, obtained from liver tissue of anesthetized and mechanically ventilated, normo-(38 °C; gray columns ) and hypothermic (27 °C; blue columns ) mice undergoing sham surgery ( light gray and light blue columns ) or cecal ligation and puncture (CLP)-induced sepsis ( darkgray and dark blue columns ) during inhalation of vehicle ( open columns ) and 100 ppm H ₂ S ( hatchedcolumns ). Data for sham-surgery are adapted from [16]. All data are mean ± SD, $ designates p < 0.05 H₂S vs. vehicle.