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Figure 2 | Critical Care

Figure 2

From: Preventing ischemic brain injury after sudden cardiac arrest using NO inhalation

Figure 2

a Representative diffusion weighted image (DWI) of brain in mice that breathed air (Air) or air supplemented with NO (iNO). White arrows indicate areas of hyperintense DWI. b Representative magnetic resonance images showing three brain slices containing regions of interest (ROI). Slice positions are identified in millimeters (+1.5, 0, or 3 mm) with respect to bregma in the coordinate space of the Allen Mouse Brain Atlas. Colored outlines indicate portions of ROI (blue: caudoputamen; red: lateral cortex; green: ventral lateral hippocampus) that intersect with these slice planes. Average apparent diffusion coefficient (ADC) values of the slice plane for mice that breathed air (Air) or NO (iNO) after cardiac arrest and cardiopulmonary resuscitation (CPR). The color bar on the right side indicates the color-code for the ADC values (μm2/ms). c Average ADC values of each three-dimensional ROI (Hipp: ventral lateral hippocampus; CPu: caudoputamen; Ctx: lateral cortex; Total: total brain) across all planes in mice that breathed air (Air, n = 6) or NO (iNO, n = 7) after cardiac arrest and CPR. p < 0.05 vs. Air.

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