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Table 4 Characteristics and outcomes of three recent meta-analyses

From: Protective mechanical ventilation in the non-injured lung: review and meta-analysis

Author, year [ref] Serpa Neto et al. 2012[38] Hemmes et al. 2013[40] Our meta-analysis
Number of studies 20 articles 8 articles 17 articles
Number of RCTs 15 articles 6 articles 17 articles
Populations ICU and surgical patients Only surgical patients ICU and surgical patients
Search strategy until (year) 2012 2012 2013
Statistical analysis Fixed effect + Mantel and Haenszel Fixed effect + Mantel and Haenszel Fixed effect + Mantel and Haenszel, when P > 25 % random effect plus DerSimonian and Laird
Number of patients 2833   1669   1362  
  PV group CV group PV group CV group PV group CV group
VT (ml/kg) 6.5 10.6 6.1 10.4 6.1 10.7
PEEP (cm H2O) 6.4 3.4 6.6 2.7 7.6 2.5
Plateau pressure (cmH2O) 16.6 21.4 16.6 20.5 17.2 19.9
Main outcome    
ALI RR 0.33; 95 %CI 0.23-0.47 RR 0.40; 95 % CI 0.22-0.70 RR 0.27; 95 % CI 0.12-0.59
Pulmonary infection RR 0.52; 95 %CI 0.33-0.82 RR 0.64; 95 % CI 0.43-0.97 RR 0.35; 95 % CI 0.25-0.63
Atelectasis RR 0.62; 95 %CI 0.41-0.95 RR 0.67; 95 % CI 0.47-0.96 RR 0.76; 95 % CI 0.33-1.37
Mortality RR 0.64; 95 %CI 0.46-0.86 No data RR 1.03; 95 % CI 0.67-1.58
ICU length of stay No data No data WMD -0.40; 95 %CI -1.02; 0.22
Hospital length of stay No data No data WMD 0.13; 95 %CI -0.73; 0.08
Homogeneity test Found heterogeneity in pulmonary infection outcome Found heterogeneity in atelectasis outcome Found heterogeneity in atelectasis, ICU length of stay and hospital length of stay outcome
  1. RCT: randomized control trial; VT: tidal volume; PEEP: positive end-expiratory pressure; PV: protective ventilation; CV: conventional ventilation; ICU: intensive care unit; RR: risk ratio; 95 % CI: 95 % confidence interval. WMD: weighted mean difference.