Table 4 Characteristics and outcomes of three recent meta-analyses
From: Protective mechanical ventilation in the non-injured lung: review and meta-analysis
Author, year [ref] | Serpa Neto et al. 2012[38] | Hemmes et al. 2013[40] | Our meta-analysis | |||
|---|---|---|---|---|---|---|
Number of studies | 20 articles | 8 articles | 17 articles | |||
Number of RCTs | 15 articles | 6 articles | 17 articles | |||
Populations | ICU and surgical patients | Only surgical patients | ICU and surgical patients | |||
Search strategy until (year) | 2012 | 2012 | 2013 | |||
Statistical analysis | Fixed effect + Mantel and Haenszel | Fixed effect + Mantel and Haenszel | Fixed effect + Mantel and Haenszel, when P > 25 % random effect plus DerSimonian and Laird | |||
Number of patients | 2833 | 1669 | 1362 | |||
PV group | CV group | PV group | CV group | PV group | CV group | |
VT (ml/kg) | 6.5 | 10.6 | 6.1 | 10.4 | 6.1 | 10.7 |
PEEP (cm H2O) | 6.4 | 3.4 | 6.6 | 2.7 | 7.6 | 2.5 |
Plateau pressure (cmH2O) | 16.6 | 21.4 | 16.6 | 20.5 | 17.2 | 19.9 |
Main outcome | ||||||
ALI | RR 0.33; 95 %CI 0.23-0.47 | RR 0.40; 95 % CI 0.22-0.70 | RR 0.27; 95 % CI 0.12-0.59 | |||
Pulmonary infection | RR 0.52; 95 %CI 0.33-0.82 | RR 0.64; 95 % CI 0.43-0.97 | RR 0.35; 95 % CI 0.25-0.63 | |||
Atelectasis | RR 0.62; 95 %CI 0.41-0.95 | RR 0.67; 95 % CI 0.47-0.96 | RR 0.76; 95 % CI 0.33-1.37 | |||
Mortality | RR 0.64; 95 %CI 0.46-0.86 | No data | RR 1.03; 95 % CI 0.67-1.58 | |||
ICU length of stay | No data | No data | WMD -0.40; 95 %CI -1.02; 0.22 | |||
Hospital length of stay | No data | No data | WMD 0.13; 95 %CI -0.73; 0.08 | |||
Homogeneity test | Found heterogeneity in pulmonary infection outcome | Found heterogeneity in atelectasis outcome | Found heterogeneity in atelectasis, ICU length of stay and hospital length of stay outcome | |||