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Table 2 Characteristics of the studies included in the meta-analysis

From: Protective mechanical ventilation in the non-injured lung: review and meta-analysis

   Protective ventilation Standard ventilation    
First author, Year [Ref] Number of patients VT (ml/kg) N VT (ml/kg) N Setting Design Primary outcome
Lee 1990 [31] 103 6 47 12 56 ICU RCT Duration of MV
Chaney 2000 [14] 25 6 12 12 16 Surg RCT Lung mechanics
Wrigge 2004 [18] 62 6 30 12 32 Surg RCT Cytokines in BAL
Koner 2004 [15] 44 6 15 10 29 Surg RCT Cytokines in blood
Wrigge 2005 [16] 44 6 22 12 22 Surg RCT Cytokines in BAL
Zupancich 2005 [17] 40 8 20 10 20 Surg RCT Cytokines in BAL
Michelet 2006 [43] 52 5 26 9 26 Surg RCT Cytokines in blood
Cai 2007 [27] 16 6 8 10 8 Surg RCT Atelectasis
Wolthius 2008 [19] 40 6 21 12 19 Surg RCT Pulmonary Inflammation
Determan 2008 [26] 40 6 21 12 19 Surg RCT Cytokines in BAL
Weingarten 2010 [20] 40 6 20 10 20 Surg RCT Oxygenation
Determann 2010 [33] 150 6 76 10 74 ICU RCT Cytokines in BAL
Pinheiro de Oliveira 2010 [32] 20 6 10 12 10 ICU RCT Cytokines in BAL
Sundar 2011 [28] 149 6 75 10 74 Surg RCT Duration of MV
Treschan 2012 [23] 101 6 50 12 51 Surg RCT Spirometry
Severgnini 2013 [24] 55 7 27 9 28 Surg RCT Change in mCPIS
Futier 2013 [25] 400 6-8 200 10-12 200 Surg RCT Pulmonary and extrapulmonary complications
  1. BAL: bronchoalveolar lavage; ICU: intensive care unit; MV: mechanical ventilation; Surg: surgical; VT: tidal volume; mCPIS: modified Clinical Pulmonary Infection Score.