Table 5 Discriminatory performance of procalcitonin for detection of bacterial pneumonia a
| Â | Cutoff | Sensitivity, % (95% CI) | Specificity, % (95% CI) | Positive PV, % (95% CI) | Negative PV, % (95% CI) | Positive likelihood ratio (95% CI) | Negative likelihood ratio, % (95% CI) |
|---|---|---|---|---|---|---|---|
Total | >0.25 μg/L | 87.0 (77.4 to 93.6) | 28.6 (19.2 to 39.5) | 52.8 (43.7 to 61.7) | 70.6 (52.5 to 84.9) | 1.22 (1.04 to 1.43) | 0.45 (0.23 to 0.89) |
|  | >0.5 μg/L | 80.5 (69.9 to 88.7) | 48.8 (37.7 to 60.0) | 59.1 (49.0 to 68.6) | 73.2 (59.7 to 84.2) | 1.57 (1.24 to 1.99) | 0.40 (0.24 to 0.66) |
|  | >1 μg/L | 71.4 (60.0 to 81 to 2) | 59.5 (48.3 to 70.1) | 61.8 (50.9 to 71.9) | 69.4 (57.5 to 79.8) | 1.76 (1.31 to 2.37) | 0.48 (0.32 to 0.71) |
Without hospital-acquired pneumonia or immune-compromising disorder | >0.25 μg/L | 90.9 (80.1 to 97.0) | 31.9 (21.2 to 44.2) | 51.6 (41.2 to 61.8) | 81.5 (61.9 to 93.7) | 1.33 (1.11 to 1.60) | 0.29 (0.12 to 0.70) |
|  | >0.5 μg/L | 85.5 (73.3 to 93.5) | 53.6 (41.2 to 65.7) | 59.5 (47.9 to 70.4) | 82.2 (68.0 to 92.0) | 1.84 (1.40 to 2.43) | 0.27 (0.14 to 0.53) |
|  | >1 μg/L | 74.6 (61.0 to 86.3) | 60.9 (48.4 to 72.4) | 60.3 (47.7 to 72.0) | 75.0 (61.6 to 85.6) | 1.91 (1.37 to 2.66) | 0.42 (0.26 to 0.68) |