Figure 1
From: Soluble platelet-endothelial cell adhesion molecule-1, a biomarker of ventilator-induced lung injury
Histological and gas-exchange findings. (A) Representative histological features of different ventilatory strategies in healthy and septic lungs. Animals ventilated with high tidal volume showed abundant pulmonary infiltrates and perivascular edema (hematoxylin-eosin, ×200). (B) PaO2/FiO2 ratios at the end of a four-hour ventilation period. ***P <0.001 (HVT versus LVT); *P <0.05 (SHVT versus SLVT). (C) Histological lung injury score. ***P <0.001 (HVT versus LVT; SHVT versus S and SLVT; SLVT versus S). C: healthy control, spontaneous breathing lung; LVT: healthy, ventilated with low tidal volume; HVT: healthy lung ventilated with high tidal volume; S: septic, spontaneous breathing rats; SLVT: septic lung ventilated with low tidal volume; SHVT: septic lung ventilated with high tidal volume. PaO2/FiO2, ratio of arterial partial pressure of oxygen to fraction of inspired oxygen.