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Table 6 Levels of soluble vascular cell adhesion molecule-1 in neonates, children and adults

From: Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Study (reference) Mean age Sepsis criteria Healthy (μg/ml)a Number of patients (healthy) Sepsis (μg/ml)a Number of patients (sepsis)
Neonates       
Figueras-Aloy and colleagues [49] 0 to 14 days SNAP-II 928 (856 to 1,005) 12 1,112 (1,072 to 1,153) 15
Austgulen and colleagues [45] 0 to 7 days Clinical 1,940 (1,100 to 3,500) 168 1,950 (1,190 to 3,495) 24
Children       
Andrys and colleagues [60] 6 to 15 years   590.8 (359.6 to 822.0) 68   
Paize and colleagues [61] 2.16 PRISM 600 (390 to 790) 40 1,550 (1,360 to 1,910) 20
Krueger and colleagues [62] 3.5 (0.2 to 16) ACCP/SCCM 766 (644 to 915) 22 1,239 (928 to 1,615) 22
Whalen and colleagues [63] 1 day to 17 years Criteria of Doughty and colleaguesb 231 ± 46 14 600 77
Nash and colleagues [64] 9 years   790 (580 to 1,060) 81   
  15 years   780 (420 to 1,000)    
Adults       
Presterl and colleagues [65] 51 APACHE II 545 (374 to 829) 20 2633 20
Knapp and colleagues [68] 51 to 55 (21 to 96) APACHE III 569 ± 98 15 1,395 ± 801 28
Soderquist and colleagues [70] 71 (10 to 91) Unknown 533 (354 to 1,018) 15 1,173 (525 to 3,500) 41
Hofer and colleagues [78] 65.9 (12.4) APACHE II 1,524.7 (991.2 to 2,038) 108 1,147.9 (883.5 to 2,074.4) 18
De Pablo and colleagues [73] 61.2 (3.2) APACHE II 890 48 1,600 52
Shapiro and colleagues [6] 57 (19) APACHE III 1,050 49 1,550 95
Andrys and colleagues [60] 46   743 (338 to 1,148) 68   
Leone and colleagues [76] 45 to 47 (16 to 21) SIRS 458 ± 123 26 1,604 ± 940 11
  1. ACCP/SCCM, American college of chest physicians/ society of critical care medicine; APACHE, acute physiology and chronic health evaluation; PRISM, pediatric risk of mortality; SIRS, systemic inflammatory response syndrome; SNAP, score for neonatal acute physiology. aData presented as mean (range) or mean ± standard deviation. bCriteria from [75]. Ages expressed in years unless otherwise stated.