Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Table 4 Levels of soluble P-selectin in neonates, children and adults

Study (reference)	Mean age	Sepsis criteria	Healthy (μg/ml)^a	Number of patients (healthy)	Sepsis (μg/ml)^a	Number of patients (sepsis)
Neonates
Figueras-Aloy and colleagues [49]	0 to 14 days	SNAP-II	272 (152 to 288)	12	244 (170 to 324)	15
Sitaru and colleagues [48]	0 days	Clinical	104 ± 71	10	222 ± 128	9
Children
Paize and colleagues [61]	2 to 16	PRISM	50 (44 to 60)	40	61 (47 to 119)	20
Adults
Mosad and colleagues [32]	3	SIRS/SOFA	28.6 ± 6		63 ± 9	176
Fijnheer and colleagues [29]	Adult	SIRS	122 ± 38	10	398 ± 203	26
Weigand and colleagues [66]	58.7 (4.4)	ACCP/SCCM	32.1 ± 5.1	7	296 ±56	14
Osmanovic and colleagues [69]	Adult	Unknown	181 ± 44	18	305 ± 158	9
Geppert and colleagues [72]	59 (35 to 85)	SIRS	116.9 ± 33.4	7	291 ± 227.4	27
Leone and colleagues [76]	45 to 47 (16 to 21)	SIRS	62 ± 20	26	129 ± 98	11

ACCP/SCCM, American college of chest physicians/society of critical care medicine; PRISM, pediatric risk of mortality; SIRS, systemic inflammatory response syndrome; SNAP, score for neonatal acute physiology; SOFA, sequential organ failure assessment. ^aData presented as mean (range) or mean ± standard deviation. Ages expressed in years unless otherwise stated.

ISSN: 1364-8535