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Table 4 Levels of soluble P-selectin in neonates, children and adults

From: Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Study (reference) Mean age Sepsis criteria Healthy (μg/ml)a Number of patients (healthy) Sepsis (μg/ml)a Number of patients (sepsis)
Neonates       
Figueras-Aloy and colleagues [49] 0 to 14 days SNAP-II 272 (152 to 288) 12 244 (170 to 324) 15
Sitaru and colleagues [48] 0 days Clinical 104 ± 71 10 222 ± 128 9
Children       
Paize and colleagues [61] 2 to 16 PRISM 50 (44 to 60) 40 61 (47 to 119) 20
Adults       
Mosad and colleagues [32] 3 SIRS/SOFA 28.6 ± 6   63 ± 9 176
Fijnheer and colleagues [29] Adult SIRS 122 ± 38 10 398 ± 203 26
Weigand and colleagues [66] 58.7 (4.4) ACCP/SCCM 32.1 ± 5.1 7 296 ±56 14
Osmanovic and colleagues [69] Adult Unknown 181 ± 44 18 305 ± 158 9
Geppert and colleagues [72] 59 (35 to 85) SIRS 116.9 ± 33.4 7 291 ± 227.4 27
Leone and colleagues [76] 45 to 47 (16 to 21) SIRS 62 ± 20 26 129 ± 98 11
  1. ACCP/SCCM, American college of chest physicians/society of critical care medicine; PRISM, pediatric risk of mortality; SIRS, systemic inflammatory response syndrome; SNAP, score for neonatal acute physiology; SOFA, sequential organ failure assessment. aData presented as mean (range) or mean ± standard deviation. Ages expressed in years unless otherwise stated.