Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Table 3 Levels of soluble L-selectin in neonates, children and adults

Study (reference)	Mean age	Sepsis criteria	Healthy (μg/ml)^a	Number of patients (healthy)	Sepsis (μg/ml)^a	Number of patients (sepsis)
Neonates
Figueras-Aloy and colleagues [49]	0 to 14 days	SNAP-II	580 (523 to 717)	12	681 (541 to 757)	15
Kourtis and colleagues [50]	0 to 2 days	Clinical	1,155	75	1,331 (1,123 to 1,427)	14
Giannaki and colleagues [47]	At term		674 ± 223	40
Rebuck and colleagues [43]	At term		463 (338 to 557)	22
Koenig and colleagues [42]	0 to 7 days		324 ± 24	10
Children
Kourtis and colleagues [59]	Children		3,356 (2,818 to 3,894)	100
Briassoulis and colleagues [19]	6.5 (2.8)	PRISM	3,750 ± 321	10	6,263 ± 3,813	10
Adults
Weigand and colleagues [66]	58.7 (4.4)	ACCP/SCCM	460	7	400	14
Kourtis and colleagues [50]	Adult		950 (700 to 1,220)	75
Schleiffenbaum and colleagues [23]	Adult		1,600 ± 800	63
Giannaki and colleagues [47]	Adult		938 ± 181	40
Rebuck and colleagues [43]	Adult		717 (410 to 822)	22
Koenig and colleagues [42]	Adult		537 ± 28	9

ACCP/SCCM, American college of chest physicians/society of critical care medicine; PRISM, pediatric risk of mortality; SNAP, score for neonatal acute physiology. ^aData presented as mean (range) or mean ± standard deviation. Ages expressed in years unless otherwise stated.

ISSN: 1364-8535