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Table 2 Levels of soluble E-selectin in neonates, children and adults

From: Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Study (reference) Mean age Sepsis criteria Healthy (μg/ml)a Number of patients (healthy) Sepsis (μg/ml)a Number of patients (sepsis)
Neonates       
Dollner and colleagues [52] 0 to 7 days Clinical 91.4 (2 to 217.8) 24 151.7 (37 to 362.2) 18
Austgulen and colleagues [45] Pre/at term Clinical 134.1 (69.5 to 280) 168 187.7 (118.4 to 262.2) 24
Edgar and colleagues [57] 0 to 7 days Clinical 71 (51 to 118) 27 135 (94 to 192) 192
Giannaki and colleagues [47] At term Clinical 139 ± 48 40   
Edgar and colleagues [55] At term Clinical 71 (51 to 118) 46 158 (94 to 207) 46
Children       
Andrys and colleagues [60] 6 to 10   57.6 (36.7 to 152.2) 68   
  11 to 15   42.1 (29.9 to 114.1) 90   
Paize and colleagues [61] 2 to 16 PRISM 100 (90 to 110) 40 230 (100 to 380) 20
Krueger and colleagues [62] 3.5 (0.2 to 16) ACCP/SCCM 68 (49 to 105) 22 131 (112 to 146) 22
Whalen and colleagues [63] 1 day to 17 years Criteria of Doughty and colleaguesb 46 ± 6 14 230 77
Nash and colleagues [64] 9   70 (35 to 121) 81   
  15   59 (25 to 119)    
Briassoulis and colleagues [19] 6.5 (2.8) PRISM 161 ± 43 10 936 ± 399 10
Adults       
Presterl and colleagues [65] 51 (30 to 67) APACHE II 48.9 (14.3 to 89.9) 20 130 (40 to 570) 20
Weigand and colleagues [66] 58.7 (4.4) ACCP/SCCM 29 (14.3 to 89.9) 7 85 14
Hynninen and colleagues [67] 49 (17.2) APACHE II    73 (62 to 89) 11
Knapp and colleagues [68] 51 (21 to 96) APACHE III 43.7 ± 20.3 15 94.5 ± 54 28
Osmanovic and colleagues [69] Adult   28.5 ± 14.3 18 118 ± 84 9
Soderquist and colleagues [70] 71 (10 to 91) Unknown 48 (20 to 97) 15 80 (22 to 200) 41
Takala and colleagues [71] 44 to 59 (17 to 86) APACHE II 45 (10 to 100) Unknown 154 (61 to 394) 20
Geppert and colleagues [72] 59 (35 to 85) SIRS 42.8 ± 19.4 7 96.2 ± 47.3 27
De Pablo and colleagues [73] 61.2 (3.2) APACHE II 48 36 98 52
Kayal and colleagues [74] 57.2 (3.9) ACCP/SCCM 40.5 ± 4.5 9 231 ± 41.8 25
Shapiro and colleagues [6] 57 (19) APACHE III 49 207 95 13
Andrys and colleagues [60] 46   54.3 (8.3 to 116.9) 68   
Giannaki and colleagues [47] Adult   48 ± 13 40   
  1. ACCP/SCCM, American college of chest physicians/society of critical care medicine; APACHE, acute physiology and chronic health evaluation; PRISM, pediatric risk of mortality; SIRS, systemic inflammatory response syndrome. aData presented as mean (range) or mean ± standard deviation. bCriteria from [75]. Ages expressed in years unless otherwise stated.