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Table 2 Levels of soluble E-selectin in neonates, children and adults

From: Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults

Study (reference)

Mean age

Sepsis criteria

Healthy (μg/ml)a

Number of patients (healthy)

Sepsis (μg/ml)a

Number of patients (sepsis)

Neonates

      

Dollner and colleagues [52]

0 to 7 days

Clinical

91.4 (2 to 217.8)

24

151.7 (37 to 362.2)

18

Austgulen and colleagues [45]

Pre/at term

Clinical

134.1 (69.5 to 280)

168

187.7 (118.4 to 262.2)

24

Edgar and colleagues [57]

0 to 7 days

Clinical

71 (51 to 118)

27

135 (94 to 192)

192

Giannaki and colleagues [47]

At term

Clinical

139 ± 48

40

  

Edgar and colleagues [55]

At term

Clinical

71 (51 to 118)

46

158 (94 to 207)

46

Children

      

Andrys and colleagues [60]

6 to 10

 

57.6 (36.7 to 152.2)

68

  
 

11 to 15

 

42.1 (29.9 to 114.1)

90

  

Paize and colleagues [61]

2 to 16

PRISM

100 (90 to 110)

40

230 (100 to 380)

20

Krueger and colleagues [62]

3.5 (0.2 to 16)

ACCP/SCCM

68 (49 to 105)

22

131 (112 to 146)

22

Whalen and colleagues [63]

1 day to 17 years

Criteria of Doughty and colleaguesb

46 ± 6

14

230

77

Nash and colleagues [64]

9

 

70 (35 to 121)

81

  
 

15

 

59 (25 to 119)

   

Briassoulis and colleagues [19]

6.5 (2.8)

PRISM

161 ± 43

10

936 ± 399

10

Adults

      

Presterl and colleagues [65]

51 (30 to 67)

APACHE II

48.9 (14.3 to 89.9)

20

130 (40 to 570)

20

Weigand and colleagues [66]

58.7 (4.4)

ACCP/SCCM

29 (14.3 to 89.9)

7

85

14

Hynninen and colleagues [67]

49 (17.2)

APACHE II

  

73 (62 to 89)

11

Knapp and colleagues [68]

51 (21 to 96)

APACHE III

43.7 ± 20.3

15

94.5 ± 54

28

Osmanovic and colleagues [69]

Adult

 

28.5 ± 14.3

18

118 ± 84

9

Soderquist and colleagues [70]

71 (10 to 91)

Unknown

48 (20 to 97)

15

80 (22 to 200)

41

Takala and colleagues [71]

44 to 59 (17 to 86)

APACHE II

45 (10 to 100)

Unknown

154 (61 to 394)

20

Geppert and colleagues [72]

59 (35 to 85)

SIRS

42.8 ± 19.4

7

96.2 ± 47.3

27

De Pablo and colleagues [73]

61.2 (3.2)

APACHE II

48

36

98

52

Kayal and colleagues [74]

57.2 (3.9)

ACCP/SCCM

40.5 ± 4.5

9

231 ± 41.8

25

Shapiro and colleagues [6]

57 (19)

APACHE III

49

207

95

13

Andrys and colleagues [60]

46

 

54.3 (8.3 to 116.9)

68

  

Giannaki and colleagues [47]

Adult

 

48 ± 13

40

  
  1. ACCP/SCCM, American college of chest physicians/society of critical care medicine; APACHE, acute physiology and chronic health evaluation; PRISM, pediatric risk of mortality; SIRS, systemic inflammatory response syndrome. aData presented as mean (range) or mean ± standard deviation. bCriteria from [75]. Ages expressed in years unless otherwise stated.