Study (reference) | Mean age | Sepsis criteria | Healthy (μg/ml)a | Number of patients (healthy) | Sepsis (μg/ml)a | Number of patients (sepsis) |
---|---|---|---|---|---|---|
Neonates | Â | Â | Â | Â | Â | Â |
Dollner and colleagues [52] | 0 to 7 days | Clinical | 91.4 (2 to 217.8) | 24 | 151.7 (37 to 362.2) | 18 |
Austgulen and colleagues [45] | Pre/at term | Clinical | 134.1 (69.5 to 280) | 168 | 187.7 (118.4 to 262.2) | 24 |
Edgar and colleagues [57] | 0 to 7 days | Clinical | 71 (51 to 118) | 27 | 135 (94 to 192) | 192 |
Giannaki and colleagues [47] | At term | Clinical | 139 ± 48 | 40 |  |  |
Edgar and colleagues [55] | At term | Clinical | 71 (51 to 118) | 46 | 158 (94 to 207) | 46 |
Children | Â | Â | Â | Â | Â | Â |
Andrys and colleagues [60] | 6 to 10 | Â | 57.6 (36.7 to 152.2) | 68 | Â | Â |
 | 11 to 15 |  | 42.1 (29.9 to 114.1) | 90 |  |  |
Paize and colleagues [61] | 2 to 16 | PRISM | 100 (90 to 110) | 40 | 230 (100 to 380) | 20 |
Krueger and colleagues [62] | 3.5 (0.2 to 16) | ACCP/SCCM | 68 (49 to 105) | 22 | 131 (112 to 146) | 22 |
Whalen and colleagues [63] | 1 day to 17 years | Criteria of Doughty and colleaguesb | 46 ± 6 | 14 | 230 | 77 |
Nash and colleagues [64] | 9 | Â | 70 (35 to 121) | 81 | Â | Â |
 | 15 |  | 59 (25 to 119) |  |  |  |
Briassoulis and colleagues [19] | 6.5 (2.8) | PRISM | 161 ± 43 | 10 | 936 ± 399 | 10 |
Adults | Â | Â | Â | Â | Â | Â |
Presterl and colleagues [65] | 51 (30 to 67) | APACHE II | 48.9 (14.3 to 89.9) | 20 | 130 (40 to 570) | 20 |
Weigand and colleagues [66] | 58.7 (4.4) | ACCP/SCCM | 29 (14.3 to 89.9) | 7 | 85 | 14 |
Hynninen and colleagues [67] | 49 (17.2) | APACHE II | Â | Â | 73 (62 to 89) | 11 |
Knapp and colleagues [68] | 51 (21 to 96) | APACHE III | 43.7 ± 20.3 | 15 | 94.5 ± 54 | 28 |
Osmanovic and colleagues [69] | Adult |  | 28.5 ± 14.3 | 18 | 118 ± 84 | 9 |
Soderquist and colleagues [70] | 71 (10 to 91) | Unknown | 48 (20 to 97) | 15 | 80 (22 to 200) | 41 |
Takala and colleagues [71] | 44 to 59 (17 to 86) | APACHE II | 45 (10 to 100) | Unknown | 154 (61 to 394) | 20 |
Geppert and colleagues [72] | 59 (35 to 85) | SIRS | 42.8 ± 19.4 | 7 | 96.2 ± 47.3 | 27 |
De Pablo and colleagues [73] | 61.2 (3.2) | APACHE II | 48 | 36 | 98 | 52 |
Kayal and colleagues [74] | 57.2 (3.9) | ACCP/SCCM | 40.5 ± 4.5 | 9 | 231 ± 41.8 | 25 |
Shapiro and colleagues [6] | 57 (19) | APACHE III | 49 | 207 | 95 | 13 |
Andrys and colleagues [60] | 46 | Â | 54.3 (8.3 to 116.9) | 68 | Â | Â |
Giannaki and colleagues [47] | Adult |  | 48 ± 13 | 40 |  |  |