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Figure 2 | Critical Care

Figure 2

From: Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model

Figure 2

aPTT at the low dabigatran (A), high dabigatran (B) and post-trauma (C) time-points. Activated partial thromboplastin time (aPTT) was obtained on a coagulometer to determine the effect of hemostatic therapy at various time points. Grey dotted lines indicate mean baseline values. Data are shown as mean ± SD. *P <0.05 versus control. PCC, prothrombin complex concentrate; aPCC, activated PCC; rFVIIa, recombinant activated factor VII; aDabi-Fab, antibody fragment to dabigatran.

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