Pharmacokinetics, hemodynamic and metabolic effects of epinephrine to prevent post-operative low cardiac output syndrome in children

Table 3 Hemodynamic and metabolic population parameters

Hemodynamic population parameters	Estimate	RSE (%)
HR₀ (b⋅min^-1)	133	3
θ_age (HR_0i = HR₀ x age_i^-0.061)	-0.061	18
HR_max (b⋅min^-1)	180	3
C₅₀ HR (μg⋅L^-1)	5.71	37
SV⋅SVR₀	0.31	3
θ_age (SV⋅SVR_0i = SV⋅SVR₀ x age_i^0.094 )	0.094	14
SV⋅SVR_max, RACHS-1 = category 2	0.44	20
SV.SVR_max, RACHS-1 = categories 3,4	0.26	20
C₅₀ SV⋅SVR (μg.L^-1)	18	59
η_HR0 (square root of ω²_{HR 0})	0.14	14
η_{C50 HR} (square root of ω²_{C 50 HR})	1.22	17
η_SV.SVR0 (square root of ω²_SV.SVR0)	0.13	17
η_SV.SVRmax (square root of ω²_SV.SVRmax)	0.23	42
Residual variability (proportional)
HR	0.08	4
MAP	0.16	4
Metabolic population parameters
GLY₀ (mmol⋅L^-1)	5.46	5
G_max	1.69	6
R_GLY (mmol⋅L^-1.min^-1)	0.04	25
C₅₀GLY (μg⋅L^-1)	0.52	9
LAC₀ (mmol⋅L^-1)	1.23	7
η_GLY0 (square root of ω²_{GLY 0})	0.21	23
η_Gmax (square root of ω²_Gmax)	0.213	26
η_RGly (square root of ω²_RGLY)	1	21
η_LAC0 (square root of ω²_LAC0)	0.33	18
Residual variability (constant additive)
GLY (mmol⋅L^-1)	2.23	5
LAC (mmol⋅L^-1)	0.5	11

HR₀, basal heart rate; HR_max, maximal HR; C₅₀HR, Ep concentration producing 50% of HR _max; SV⋅SVR, product of stoke volume by systemic vascular resistances; SV⋅SVR₀, basal SV⋅SVR value; SV.SVR_max, maximal SV⋅SVR value; C₅₀SV⋅SVR_, Ep concentration producing 50% of SV⋅SVR_max; RACHS-1, risk adjustment for congenital heart surgery 1; GLY₀, basal plasma glucose level; R_GLY, glucose zero-order production rate; G_max, relative maximal increase in R_GLY; C₅₀GLY, Ep concentration that produces 50% of the maximal response on plasma glucose level; LAC₀, basal plasma lactate level; RSE, relative standard error; η, between-subject variability (BSV); θ_age, age influential parameter.

ISSN: 1364-8535