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Table 1 Patient characteristics and baseline kinetic and dynamic data

From: Pharmacokinetics, hemodynamic and metabolic effects of epinephrine to prevent post-operative low cardiac output syndrome in children

Patient characteristics (n = 39)

Values

Demographics

 

Age, months

3.9 (0.1 to 189)

Gender, male, n (%)

26 (66.6%)

Body weight, kg

4.5 (2.5 to 58)

Preoperative physiological profile

 

RACHS-1, categories, median (range)

3 (2 to 4)

Category 2, n

16

Category 3, n

17

Category 4, n

6

Prothrombin activity (%)

80 (50 to 100)

Creatinine clearance, mLmin-11.73 m(2) -1

91 (22 to 200)

Per-operative course

 

Duration of CPB, minutes

107 (52 to 222)

Aortic cross-clamping time, minutes

64 (9 to 140)

Postoperative course

 

Ep infusion duration, days

1.5 (1 to 13)

pCVICU length of stay, days

3 (2 to 23)

Baseline kinetic and dynamic parameters

 

Ep concentration, μgL-1

0.062 (0.037 to 0.25)

Heart rate, beatsmin-1

135 (70 to 180)

Mean arterial pressure, mmHg

51 (25 to 65)

Plasma glucose level, mmolL-1

6.2 (4 to 10.1)

Plasma lactate level, mmolL-1

1 (0.5 to 3)

  1. RACHS, risk adjustment for congenital heart surgery; n, number; CPB, cardiopulmonary bypass; min, minutes; Ep, epinephrine; pCVICU, pediatric cardiovascular intensive care unit. Values represent median and the presentation of the value in parentheses defined the range from (min to max).