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Table 1 Timeline of vital signs and ventilator parameters

From: Lung protection during non-invasive synchronized assist versus volume control in rabbits

 

Mode

Pre-ALI

Post-ALI

1 hour

2 hours

3 hours

4 hours

5 hours

6 hours

P-value (time)

P-value (mode)

Mean BP, mmHg

NIV-NAVA

83$

70

79$

70

68

61

61

61

NS

P <0.05 at Pre-ALI and 1 h

(77,88)

(50,87)

(73,86)

(66,80)

(62,77)

(58,75)

(54,70)

(50,68)

 

VC

67

72

72

73

65

64

56

66

NS

(64,80)

(64,80)

(65,77)

(67,77)

(57,68)

(56,67)

(52,67)

(53,70)

Heart rate, bpm

NIV-NAVA

156

202 #

172

171

174

179

176

178

P <0.05

NS

(152,169)

(190,212)

(153,181)

(163,193)

(170,179)

(166,183)

(160,181)

(161,190)

Post -LI

 

VC

150

193 #

162

172

176

179

176

174

P <0.05

(142,195)

(178,202)

(148,183)

(151,185)

(166,198)

(166,183)

(160,181)

(150,196)

Post-ALI

Body temperature, °C

NIV-NAVA

38.9

39.1

39.2

38.9

39.0

38.9

39.0

38.9

NS

NS

(38.7,39.1)

(38.9,39.2)

(38.9,39.5)

(38.8,39.6)

(38.8,39.4)

(38.6,39.3)

(38.6,39.3)

(38.7,39.2)

 

VC

39.0

39.1

39.0

39.2

39.2

39.2

39.0

39.1

NS

(38.5,39.3)

(38.5,39.2)

(38.8,39.2)

(38.9,39.3)

(39.0,39.6)

(38.8,39.4)

(38.8,39.1)

(38.9-39.3)

SAO2,%

NIV-NAVA

99.1

91.1# $

98

97.3

98.7

98.4

98.8

98.6

P <0.05

P <0.05 at Post-ALI

(98.3,99.3)

(75.3,97)

(95.7,99)

(93.7,98.9)

(96.5)

(97.1,98.8)

(97,99)

(97.4,99.1)

 

VC

98.5

92.1

98.8

98.7

98.6

98.9

98.8

99.1

NS

(97.4,99.1)

(77.2,97)

(98,99.4)

(98.5,99)

(97.4,99)

(98.2,99.3)

(98.2,99.1)

(98.1,99.1)

PaCO2, mmHg

NIV-NAVA

55.2

73.7 #$

54.5

50.6

45.8

51.6

50.7

53.8

P <0.05

P <0.05 Post -LI

(51.7,59.9)

(62.8,77.9)

(42.8,63.6)

(47.3,59.5)

(40.8,63)

(38.8,56.1)

(38.9,56.9)

(32.8,61)

 

VC

56.4

56.6

50.15

49

50.7

46.2

47.1

47.3

NS

(47.2,57.9)

(45.3,63.2)

(45.5,55.7)

(42,55)

(40,55.6)

(39.3,48.8)

(42,52.1)

(38.6,60.8)

Ventilation rate per minute

NIV-NAVA

30

47#$

36$

36$

32

29

37$

37$

P <0.05

P <0.05 Post-ALI

(± 7)

(±15)

(±8)

(±9)

(±7)

(±6)

(±24)

(±25)

 

VC

28

26

26

26

27

27

28

28

NS

(±9)

(±6)

(±4)

(±4)

(±3)

(±3)

(±2)

(±2)

Cdyn, mL/cm H2O

NIV-NAVA

1.73$

0.94#

-

-

-

-

-

1.18*

P <0.01

P <0.05 Pre-ALI

(±0.25)

(±0.25)

(±0.14)

 

VC

2.43

1.26#

-

-

-

-

-

1.30#

P <0.05

(±0.76)

(0.33)

(±0.29)

vs. Pre-ALI

Cstat, mL/cm H2O

VC

2.5

2.1#

2.3#

2.0#$

1.9#$

1.9#$

1.7#$

1.8#$

P < 0.001

-

(2.5,2.8)

(1.7,2.3)

(2.1,2.7)

(1.9,2.4)

(1.5,2.3)

(1.5,2.3)

(1.5,2.0)

(1.5,2.1)

All vs. Pre-ALI and 1 h

Plateau pressure, cmH2O

VC

8.4

11.9#

11.5#

11.9#

12.7#

12.3#

12.5#

12.9#

P <0.05

-

(7.2,9.0)

(10.8,12.6)

(9.2,13.7)

(10.5,14.0)

(10.3,13.4)

(10.8,14.3)

(11.3,14.7)

(11.1,14.0)

All vs. Pre-ALI

Inspiratory flow, mL/s

VC

19.2

21.2

20.9

21.3

21.6

21.7

23.2

23.6

NS

-

  

(15.2,21.1)

(17.6,33.1)

(15.9,23.7)

(15.8,23.8)

(16.0,30.0)

(20.7,29.9)

(20.6,29.6)

(20.4,31.7)

  
  1. Median values (25th to75th percentile) unless otherwise indicated, by ‘ ± ’. BP, blood pressure; SAO2, saturation from arterial blood gas; Cdyn dynamic compliance; PaCO2, arterial carbon dioxide; NIV-NAVA, non-invasive NAVA; VC, volume control; ALI, acute lung injury. #Within a mode, significantly different from prior to acute lung injury (Pre-ALI); vs., versus; NS, not significant. *Within a mode, significantly different from Post-ALI. $Between modes, significantly different at specific time point.