From: Lung protection during non-invasive synchronized assist versus volume control in rabbits
Mode | Pre-ALI | Post-ALI | 1 hour | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | P-value (time) | P-value (mode) | |
---|---|---|---|---|---|---|---|---|---|---|---|
Mean BP, mmHg | NIV-NAVA | 83$ | 70 | 79$ | 70 | 68 | 61 | 61 | 61 | NS | P <0.05 at Pre-ALI and 1 h |
(77,88) | (50,87) | (73,86) | (66,80) | (62,77) | (58,75) | (54,70) | (50,68) | ||||
VC | 67 | 72 | 72 | 73 | 65 | 64 | 56 | 66 | NS | ||
(64,80) | (64,80) | (65,77) | (67,77) | (57,68) | (56,67) | (52,67) | (53,70) | ||||
Heart rate, bpm | NIV-NAVA | 156 | 202 # | 172 | 171 | 174 | 179 | 176 | 178 | P <0.05 | NS |
(152,169) | (190,212) | (153,181) | (163,193) | (170,179) | (166,183) | (160,181) | (161,190) | Post -LI | |||
VC | 150 | 193 # | 162 | 172 | 176 | 179 | 176 | 174 | P <0.05 | ||
(142,195) | (178,202) | (148,183) | (151,185) | (166,198) | (166,183) | (160,181) | (150,196) | Post-ALI | |||
Body temperature, °C | NIV-NAVA | 38.9 | 39.1 | 39.2 | 38.9 | 39.0 | 38.9 | 39.0 | 38.9 | NS | NS |
(38.7,39.1) | (38.9,39.2) | (38.9,39.5) | (38.8,39.6) | (38.8,39.4) | (38.6,39.3) | (38.6,39.3) | (38.7,39.2) | ||||
VC | 39.0 | 39.1 | 39.0 | 39.2 | 39.2 | 39.2 | 39.0 | 39.1 | NS | ||
(38.5,39.3) | (38.5,39.2) | (38.8,39.2) | (38.9,39.3) | (39.0,39.6) | (38.8,39.4) | (38.8,39.1) | (38.9-39.3) | ||||
SAO2,% | NIV-NAVA | 99.1 | 91.1# $ | 98 | 97.3 | 98.7 | 98.4 | 98.8 | 98.6 | P <0.05 | P <0.05 at Post-ALI |
(98.3,99.3) | (75.3,97) | (95.7,99) | (93.7,98.9) | (96.5) | (97.1,98.8) | (97,99) | (97.4,99.1) | ||||
VC | 98.5 | 92.1 | 98.8 | 98.7 | 98.6 | 98.9 | 98.8 | 99.1 | NS | ||
(97.4,99.1) | (77.2,97) | (98,99.4) | (98.5,99) | (97.4,99) | (98.2,99.3) | (98.2,99.1) | (98.1,99.1) | ||||
PaCO2, mmHg | NIV-NAVA | 55.2 | 73.7 #$ | 54.5 | 50.6 | 45.8 | 51.6 | 50.7 | 53.8 | P <0.05 | P <0.05 Post -LI |
(51.7,59.9) | (62.8,77.9) | (42.8,63.6) | (47.3,59.5) | (40.8,63) | (38.8,56.1) | (38.9,56.9) | (32.8,61) | ||||
VC | 56.4 | 56.6 | 50.15 | 49 | 50.7 | 46.2 | 47.1 | 47.3 | NS | ||
(47.2,57.9) | (45.3,63.2) | (45.5,55.7) | (42,55) | (40,55.6) | (39.3,48.8) | (42,52.1) | (38.6,60.8) | ||||
Ventilation rate per minute | NIV-NAVA | 30 | 47#$ | 36$ | 36$ | 32 | 29 | 37$ | 37$ | P <0.05 | P <0.05 Post-ALI |
(± 7) | (±15) | (±8) | (±9) | (±7) | (±6) | (±24) | (±25) | ||||
VC | 28 | 26 | 26 | 26 | 27 | 27 | 28 | 28 | NS | ||
(±9) | (±6) | (±4) | (±4) | (±3) | (±3) | (±2) | (±2) | ||||
Cdyn, mL/cm H2O | NIV-NAVA | 1.73$ | 0.94# | - | - | - | - | - | 1.18* | P <0.01 | P <0.05 Pre-ALI |
(±0.25) | (±0.25) | (±0.14) | |||||||||
VC | 2.43 | 1.26# | - | - | - | - | - | 1.30# | P <0.05 | ||
(±0.76) | (0.33) | (±0.29) | vs. Pre-ALI | ||||||||
Cstat, mL/cm H2O | VC | 2.5 | 2.1# | 2.3# | 2.0#$ | 1.9#$ | 1.9#$ | 1.7#$ | 1.8#$ | P < 0.001 | - |
(2.5,2.8) | (1.7,2.3) | (2.1,2.7) | (1.9,2.4) | (1.5,2.3) | (1.5,2.3) | (1.5,2.0) | (1.5,2.1) | All vs. Pre-ALI and 1 h | |||
Plateau pressure, cmH2O | VC | 8.4 | 11.9# | 11.5# | 11.9# | 12.7# | 12.3# | 12.5# | 12.9# | P <0.05 | - |
(7.2,9.0) | (10.8,12.6) | (9.2,13.7) | (10.5,14.0) | (10.3,13.4) | (10.8,14.3) | (11.3,14.7) | (11.1,14.0) | All vs. Pre-ALI | |||
Inspiratory flow, mL/s | VC | 19.2 | 21.2 | 20.9 | 21.3 | 21.6 | 21.7 | 23.2 | 23.6 | NS | - |
(15.2,21.1) | (17.6,33.1) | (15.9,23.7) | (15.8,23.8) | (16.0,30.0) | (20.7,29.9) | (20.6,29.6) | (20.4,31.7) |