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Table 2 Cohort characteristics and outcomes

From: Extracorporeal membrane oxygenation in adult patients with hematologic malignancies and severe acute respiratory failure

 

All patients N= 14

Survivors n= 7

Nonsurvivors n= 7

P value

Characteristics at ICU admission

    

 Age

32 (22–51)

23 (21–44)

48 (30–58)

0.14

 Male sex

8

4

4

1.00

 CCI

2 (2–2)

2 (2–2)

2 (2–4)

0.48

 SAPS II

51 (42–65)

56 (43–63)

45 (39–68)

0.90

 Prior allogeneic stem cell transplantation

4

0

4

<0.01

 Days from diagnosis of HM to ECMO

87 (6–907)

0 ((−1)–116)

759 (69–1,228)

0.04

 Days from ICU admission to ECMO

2 (0–3)

1 (0–2)

3 (1–11)

0.08

 Days from intubation to ECMO

2 (1–5)

1 (0–2)

3 (1–9)

0.17

Characteristics at ECMO baseline

    

 SOFA score

12 (11–13)

12 (12–19)

12 (11–15)

0.79

 Lung injury score

3.3 (3.3–3.7)

3.3 (2.3–3.7)

3.5 (3.3–3.8)

0.09

 PaO2/FiO2 ratio

60 (53–65)

63 (51–106)

60 (48–61)

0.44

 pH

7.29 (7.23–7.37)

7.29 (7.23–7.39)

7.37 (7.21–7.46)

0.52

 PaCO2, mm Hg

49 (43–59)

41 (38–49)

55 (48–72)

0.05

 Lactate, mM

2.2 (1.6–4.8)

3.8 (1.6–7.1)

2.0 (1.0–5.0)

0.34

 Hemoglobin, g/dl

9.4 (8.8–10.4)

9.4 (8.6–10.5)

9.8 (8.4–10.4)

0.90

 Leukocytes, G/L

6.0 (2.5–12.6)

11.0 (3.6–17.0)

5.6 (2.0–12.8)

0.34

 Platelets, G/L

38 (30–113)

64 (29–201)

35 (10–88)

0.21

 Prothrombin time, %

70 (43–74)

50 (18–72)

73 (64–78)

0.22

 Fibrinogen, mg/dl

436 (220–522)

473 (160–627)

421 (294–531)

1.00

 Etiology of ARF determineda

7

5

2

0.29

 Clinical diagnosis of pneumonia

10

3

7

0.07

Characteristics during ECMO

    

 Venoarterial ECMO

3

3

0

0.19

 Duration of ECMO therapy, days

8.5 (4–16)

4 (3–9)

10 (7–28)

0.08

 Diagnosis of HM on ECMO

4

4

0

0.07

 Chemotherapy on ECMO

5

4

1

0.27

 Vasopressors

14

7

7

na

 Hemofiltration

5

2

3

1.00

 Major bleeding events

5

1

4

0.27

 Number of packed red blood cell units

8 (4–14)

4 (3–8)

14 (6–27)

0.02

 Number of platelet concentrates

5 (1–17)

2 (0–5)

23 (14–26)

0.01

Outcome

    

 ICU LOS, days

22 (14–42)

22 (21–77)

18 (11–40)

0.12

 Hospital LOS, days

56 (44–101)

63 (49–110)

45 (15–133)

0.46

 ICU and hospital survival, n (%)

7 (50%)

   
  1. Data are given as median and interquartile range or n, respectively; ARF, acute respiratory failure; CCI, Charlson comorbidity index [26]; HM, hematologic malignancy; ICU, intensive care unit; ECMO, extracorporeal membrane oxygenation; LOS, length of stay; na, not applicable; SAPS II, Simplified Acute Physiology Score at ICU admission [27]; SOFA score, Sequential Organ Failure Assessment Score at ECMO Baseline [29]; amicrobiologic pathogen detected or histologic proof of HM in lung biopsy.
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