Figure 3
From: Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study
Neurofilament receiver operating characteristic curves for Intensive Care Unit–acquired weakness. Overview of discriminative power of different neurofilament measures. A) displays peak neurofilament levels at any time during admission. B) displays the highest neurofilament level and C) cumulative neurofilament level before muscle strength assessment was possible, in a diagnostically relevant cohort of patients (see text for explanation). The number of patients analyzed per curve is denoted as N: number of patients without ICU-AW/number of patients with ICU-AW. Some additional patients are excluded in C) when compared to B), because both admission and ICU day 4 samples needed to be present to calculate cumulative neurofilament levels (that is, area under the neurofilament curve). AUC, area under the receiver operating characteristic curve; MRC, Medical Research Council; NfH, neurofilaments.