Figure 7From: The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illnessTNF-α production in response to sublethal or lethal E. coli infusion, with or without C4BP and Protein S (PS) supplementation. C4BP and PS were administered at doses of 20 mg/kg and 3 mg/kg, respectively. SLEC, 10% of a lethal dose of E. coli; LEC, 100% lethal dose dose of E. coli. Adapted from Taylor et al [12].Back to article page