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Table 4 Area under ROC curves of Day 0 and Day 2 biomarkers for prediction of mortality

From: Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study

Biomarkers

ICU day

AUC (95% CI)

Cutoff values*

Sensitivity

Specificity

PPV

NPV

Global markers

       

  Platelet

Day 0

0.58 (0.41 to 0.74)

117 ( × 103/μL)

0.41

0.79

0.32

0.84

 

2

0.81 (0.64 to 0.91)

66 ( × 103/μL)

0.81

0.79

0.48

0.94

  PT-INR

Day 0

0.53 (0.34 to 0.72)

1.2

0.53

0.71

0.31

0.86

 

2

0.68 (0.47 to 0.84)

1.5

0.61

0.81

0.43

0.89

  FDP

Day 0

0.61 (0.42 to 0.76)

21 (μg/mL)

0.61

0.65

0.29

0.87

 

2

0.61 (0.41 to 0.77)

22 (μg/mL)

0.67

0.65

0.31

0.89

Thrombin generation

       

  TAT

Day 0

0.77 (0.62 to 0.87)

18 (ng/mL)

0.81

0.77

0.46

0.94

 

2

0.83 (0.65 to 0.93)

16 (ng/mL)

0.67

0.92

0.67

0.92

Anticoagulant activity

       

  PC

Day 0

0.64 (0.45 to 0.79)

37 (%)

0.53

0.75

0.35

0.87

 

2

0.76 (0.53 to 0.89)

22 (%)

0.61

0.97

0.82

0.91

Fibrinolytic activity

       

  Plasminogen

Day 0

0.64 (0.45 to 0.79)

61 (%)

0.81

0.52

0.29

0.91

 

2

0.75 (0.57 to 0.87)

50 (%)

0.81

0.67

0.38

0.93

  PAI-1

Day 0

0.81 (0.64 to 0.91)

269 (ng/mL)

0.85

0.71

0.38

0.96

 

2

0.91 (0.79 to 0.96)

81.4 (ng/mL)

0.69

0.97

0.82

0.94

  1. AUC, area under the curve; CI, confidence interval; FDP, fibrin degradation products; NPV, negative predictive value; PAI-1, plasminogen activator inhibitor-1; PC, protein C activity; PPV, positive predictive value; PT-INR, prothrombin time-international normalized ratio; ROC, receiver operating characteristic; TAT, thrombin-antithrombin complex.
  2. *Cutoff values were calculated to maximize the sum of sensitivity and specificity.