Biomarkers | ICU day | AUC (95% CI) | Cutoff values* | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|---|---|---|
Global markers | Â | Â | Â | Â | Â | Â | Â |
  Platelet | Day 0 | 0.58 (0.41 to 0.74) | 117 ( × 103/μL) | 0.41 | 0.79 | 0.32 | 0.84 |
 | 2 | 0.81 (0.64 to 0.91) | 66 ( × 103/μL) | 0.81 | 0.79 | 0.48 | 0.94 |
  PT-INR | Day 0 | 0.53 (0.34 to 0.72) | 1.2 | 0.53 | 0.71 | 0.31 | 0.86 |
 | 2 | 0.68 (0.47 to 0.84) | 1.5 | 0.61 | 0.81 | 0.43 | 0.89 |
  FDP | Day 0 | 0.61 (0.42 to 0.76) | 21 (μg/mL) | 0.61 | 0.65 | 0.29 | 0.87 |
 | 2 | 0.61 (0.41 to 0.77) | 22 (μg/mL) | 0.67 | 0.65 | 0.31 | 0.89 |
Thrombin generation | Â | Â | Â | Â | Â | Â | Â |
  TAT | Day 0 | 0.77 (0.62 to 0.87) | 18 (ng/mL) | 0.81 | 0.77 | 0.46 | 0.94 |
 | 2 | 0.83 (0.65 to 0.93) | 16 (ng/mL) | 0.67 | 0.92 | 0.67 | 0.92 |
Anticoagulant activity | Â | Â | Â | Â | Â | Â | Â |
  PC | Day 0 | 0.64 (0.45 to 0.79) | 37 (%) | 0.53 | 0.75 | 0.35 | 0.87 |
 | 2 | 0.76 (0.53 to 0.89) | 22 (%) | 0.61 | 0.97 | 0.82 | 0.91 |
Fibrinolytic activity | Â | Â | Â | Â | Â | Â | Â |
  Plasminogen | Day 0 | 0.64 (0.45 to 0.79) | 61 (%) | 0.81 | 0.52 | 0.29 | 0.91 |
 | 2 | 0.75 (0.57 to 0.87) | 50 (%) | 0.81 | 0.67 | 0.38 | 0.93 |
  PAI-1 | Day 0 | 0.81 (0.64 to 0.91) | 269 (ng/mL) | 0.85 | 0.71 | 0.38 | 0.96 |
 | 2 | 0.91 (0.79 to 0.96) | 81.4 (ng/mL) | 0.69 | 0.97 | 0.82 | 0.94 |