Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study

Table 3 Area under the ROC curves of biomarkers at baseline for prediction of overt DIC

Biomarkers (Day 0)	AUC (95% CI)	Cutoff values*	Sensitivity	Specificity	PPV	NPV
Global markers
Platelet	0.65 (0.51 to 0.76)	158 (× 10³/μL)	0.62	0.65	0.62	0.65
PT-INR	0.61 (0.48 to 0.73)	1.3	0.62	0.63	0.61	0.64
APTT	0.61 (0.48 to 0.73)	42 (sec)	0.54	0.75	0.67	0.64
Fibrinogen	0.64 (0.51 to 0.76)	310 (mg/dL)	0.54	0.78	0.69	0.65
FDP	0.67 (0.54 to 0.78)	28 (μg/mL)	0.43	0.88	0.76	0.63
Thrombin generation
TAT	0.77 (0.64 to 0.86)	15 (ng/mL)	0.67	0.85	0.81	0.72
SF	0.67 (0.54 to 0.78)	7.9 (μg/mL)	0.77	0.54	0.61	0.72
Anticoagulant activity
PC	0.85 (0.76 to 0.91)	46 (%)	0.81	0.79	0.79	0.82
AT	0.76 (0.63 to 0.85)	46 (%)	0.60	0.85	0.78	0.69
Fibrinolytic activity
Plasminogen	0.76 (0.63 to 0.85)	52 (%)	0.60	0.79	0.73	0.67
α2-PI	0.79 (0.67 to 0.88)	70 (%)	0.81	0.67	0.70	0.79
PAI-1	0.87 (0.78 to 0.92)	269 (ng/mL)	0.72	0.92	0.89	0.78
PIC	0.49 (0.36 to 0.63)	1.9 (μg/mL)	0.35	0.89	0.76	0.59
Endothelial activation
sES	0.59 (0.45 to 0.72)	67 (ng/mL)	0.51	0.72	0.62	0.61

α2-PI, α2-plasmin inhibitor activity; APTT, activated partial thromboplastin time; AT, antithrombin activity; AUC, area under the curve; CI, confidence interval; FDP, fibrin degradation products; NPV, negative predictive value; PAI-1, plasminogen activator inhibitor-1; PC, protein C activity; PIC, plasmin-α2-plasmin inhibitor complex; PPV, positive predictive value; PT-INR, prothrombin time-international normalized ratio; ROC, receiver operating characteristic; sES, soluble E selectin; SF, soluble fibrin; TAT, thrombin- antithrombin complex. *Cutoff values were calculated to maximize the sum of sensitivity and specificity.

ISSN: 1364-8535