Skip to main content

Table 1 Baseline characteristics and outcomes of the 77 patients with sepsis

From: Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study

 

All patients (n = 77)

Develop DIC (n = 37)

No DIC (n = 40)

P- value*

Demographics

    

  Age (years)

69.9 ± 12.9

70.7 ± 13.2

69.1 ± 12.7

0.58

  Male

42 (54.5)

16 (43.2)

26 (65.0)

0.069

Source of sepsis

    

  Pulmonary infection

15 (19.5)

7 (18.9)

8 (20.0)

0.91

  Abdominal infection

43 (55.8)

22 (59.5)

21 (52.5)

0.54

  Urinary tract infection

5 (6.5)

3 (8.1)

2 (5.0)

0.58

  Soft tissue infection

11 (14.3)

3 (8.1)

8 (20.0)

0.13

  Blood stream infection

2 (2.6)

2 (5.4)

0 (0.0)

0.084

Comorbidities

    

  IHD

7 (9.1)

2 (5.4)

5 (12.5)

0.27

  CHF

2 (2.6)

0 (0.0)

2 (5.0)

0.11

  Arrhythmia

3 (3.9)

3 (8.1)

0 (0.0)

0.033

  COPD

6 (7.8)

1 (2.7)

5 (12.5)

0.094

  CKD

10 (13.0)

6 (16.2)

4 (10.0)

0.42

  CVD

3 (3.9)

2 (5.4)

1 (2.5)

0.51

Severity of illness

    

  APACHE II score

25.4 ± 7.9

28.8 ± 8.2

22.2 ± 6.1

0.0002

Organ dysfunction (days 0 to 5)

    

  max SOFA score**

9 (7 to 11)

10 (9 to 14)

7 (4 to 9)

0.0001

Prognosis

    

  ICU-free days

18 (10 to 21)

16 (0 to 19)

21 (17 to 23)

0.0001

  28-day mortality

15 (19.5)

13 (35.1)

2 (5.0)

0.0005

  1. Data are expressed as mean ± SD, median (interquartile range), or No. (%).
  2. APACHE, acute physiology and chronic health evaluation; CHF, chronic heart failure; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVD, cerebrovascular disease; IHD, ischemic heart disease.
  3. *Comparison of groups with and without subsequent development of overt DIC.
  4. **maximum SOFA scores except for score of coagulation (platelet count) during the first five days of ICU stay.