Table 1 Baseline demographics/disease severity, and concomitant diseases
iHD group | CVVH group | P value | ||
|---|---|---|---|---|
(n = 128) | (n = 122) | |||
Age (years) | 60.8 ± 13.4 | 62.3 ± 14.5 | 0.41 | |
Gender (male) | 81 (63.3%) | 75 (61.5%) | 0.97a* | |
Major category (nr. of patients) | Medical | 120 (93.8%) | 115 (94.3%) | 0.95a* |
Postsurgery | 8 (6.3%) | 5 (4.1%) | 0.66a | |
Posttrauma | 0 | 2 (1.6%) | 0.46a | |
Body weight (kg) | 82.1 ± 22.8 | 86.1 ± 25.2 | 0.28 | |
Temperature (°Celsius) | 37.5 ± 1.2 | 37.5 ± 1.3 | 0.74 | |
Hemoglobin (mg/dl)/(hematocrit) (%) | 10.6 ± 1.7 | 10.4 ± 1.7 | 0.30 | |
[31.7 ± 5.8] | [31.4 ± 5.4] | [0.72] | ||
Serum creatinine (mg/dl) | 3.64 ± 2.3 | 3.57 ± 1.9 | 0.81 | |
Serum urea (mg/dl) | 159.7 ± 86.5 | 156.7 ± 77.1 | 0.77 | |
Serum potassium (mM) | 4.66 ± 0.8 | 4.65 ± 0.9 | 0.91 | |
Baseline blood pH | 7.32 ± 0.2 | 7.32 ± 0.1 | 0.82 | |
Baseline HCO3– | 22.6 ± 6.8 | 21.8 ± 5.4 | 0.34 | |
Urine output (within 24 hours before randomization; ml) | 927.1 ± 1318.4 | 708.5 ± 937.8 | 0.10 | |
Days in ICU until randomization | 1.0 [0–3.0]b | 1.0 [0–2.3]b | 0.82 | |
Days from ICU admission until start of RRT | 1.0 [0–4.0]b | 1.0 [0–3.0]b | 0.55 | |
Need for mechanical ventilation (at study day 1) | 113 (88.3%) | 103 (84.4%) | 0.88 | |
paO2/FiO2 ratio (in all patients at study day 1) | 197.3 ± 107.9 | 208.7 ± 106.8 | 0.45 | |
Need for (any) vasopressor (at study day 1) | 104 (81.2%) | 106 (86.9%) | 0.79a* | |
Key hemodynamic variables (at study day 1) | Heart rate (/min) | 104.0 ± 26.1 | 104.7 ± 20.9 | 0.81 |
Systolic blood pressure (mm Hg) | 111.6 ± 22.5 | 109.8 ± 19.4 | 0.51 | |
Diastolic blood pressure (mm Hg) | 56.4 ± 11.1 | 53.0 ± 13.6 | 0.04 | |
Central venous pressure (cmH2O) | 14.7 ± 5.3 | 14.2 ± 5.41 | 0.52 | |
Reason for ARF/need for RRT (number of patients) | Cardiogenic failure/ shock | 26 (20.3%) | 20 (16.4%) | 0.61a* |
Sepsis-induced | 85 (66.4%) | 85 (69.7%) | 0.89* | |
Hemorrhagic | 2 (1.6%) | 3 (2.5%) | 0.96* | |
No shock present | 7 (5.5%) | 5 (4.1%) | 0.85* | |
Obstruction-induced | 0 | 3 (2.5%) | 0.24* | |
Unknown | 8 (6.3%) | 9 (7.4%) | 0.94* | |
APACHE-II score | 28.5 ± 7.9 | 28.8 ± 9.6 | 0.79 | |
SAPS-II score | 66.1 ± 18.1 | 63.8 ± 17.6 | 0.34 | |
SOFA score | 13.2 ± 3.9 | 13.0 ± 4.0 | 0.66 | |
TISS-28 score | 45.0 ± 10.3 | 47.1 ± 10.2 | 0.11 | |
Concomitant disease(s) (number of patients; multiple possible) | Atherosclerosis/ischemic HF/AMI | 59 (46.1%) | 61 (50.0%) | 0.80* |
Congestive heart failure | 19 (14.8%) | 20 (16.4%) | 0.91* | |
Arterial hypertension | 41 (32.0%) | 33 (27.1%) | 0.61* | |
Obstructive pulmonary disease | 15 (11.7%) | 13 (10.7%) | 0.97* | |
Diabetes mellitus | 22 (17.2%) | 18 (14.7%) | 0.78* | |
Neurologic/psychiatric/post-stroke | 27 (21.1%) | 29 (23.8%) | 0.80* | |
Malignancy (solid/hematologic) | 30/23 | 17/22 | 0.15* | |
(23.4%/17.9%) | (13.9%/18.0%) | (0.88)* | ||
Pancreatitis | 9 (7.0%) | 8 (6.5%) | 0.91* | |
Postresuscitation | 5 (3.9%) | 10 (8.2%) | 0.28* | |
Posttransplantation | 8 (6.3%) | 7 (5.7%) | 0.92* | |
Chronic viral infection | 6 (4.7%) | 4 (3.3%) | 0.82* | |