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Table 3 Prognostic accuracy of presepsin, procalcitonin and clinical risk scores a

From: Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial

ICU survival

28 - day survival

90 - day survival

 

AUC (95% CI)

Optimal cutoff

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

LR+

LR-

AUC (95% CI)

Optimal cutoff

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

LR+

LR-

AUC (95% CI)

Optimal cutoff

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

LR+

LR-

Presepsin

                        

Day 1

0.69 (0.58 to 0.79)

1631

66.7

74.0

71

70

2.56

0.45

0.72 (0.61 to 0.82)

1631

67.4

70.9

64

74

2.32

0.46

0.66 (0.55 to 0.77)

1631

62.5

71.4

76

58

2.19

0.53

Day 2

0.70 (0.59 to 0.87)

1718

69.4

73.5

72

71

2.62

0.42

0.74 (0.64 to 0.85)

1718

74.4

72.7

68

78

2.73

0.35

0.68 (0.57 to 0.79)

1407

77.2

61.0

73

66

1.98

0.37

Day 7

0.74 (0.64 to 0.84)

1606

72.0

70.0

71

71

2.40

0.40

0.74 (0.64 to 0.84)

2028

63.6

76.8

68

73

2.74

0.47

0.70 (0.60 to 0.81)

1453

70.7

64.3

73

61

1.98

0.46

Procalcitonin

                        

Day 1

0.56 (0.44 to 0.68)

14.27

60.4

58.0

58

60

1.44

0.68

0.55 (0.44 to 0.67)

14.27

60.5

56.4

52

65

1.39

0.70

0.53 (0.41 to 0.65)

14.27

57.1

57.1

64

50

1.33

0.75

Day 2

0.55 (0.44 to 0.67)

8.88

60.4

55.1

57

59

1.35

0.72

0.53 (0.41 to 0.65)

8.88

59.5

52.7

49

63

1.26

0.77

0.55 (0.43 to 0.67)

8.88

60.7

58.5

67

52

1.46

0.67

Day 7

0.64 (0.54 to 0.75)

1.51

56.0

74.0

68

63

2.15

0.59

0.65 (0.54 to 0.76)

1.47

61.4

73.2

64

71

2.29

0.53

0.63 (0.52 to 0.74)

1.47

55.2

76.2

76

55

2.32

0.59

SOFA score

                        

Day 1

0.69 (0.59 to 0.80)

9

65.3

68.8

68

66

2.09

0.50

0.68 (0.58 to 0.79)

9

67.4

66.7

62

72

2.02

0.49

0.68 (0.57 to 0.79)

9

61.4

70.0

74

57

2.05

0.55

Day 2

0.67 (0.56 to 0.78)

8

73.9

54.2

61

68

1.61

0.48

0.72 (0.61 to 0.82)

9

70.0

64.8

60

74

1.99

0.46

0.64 (0.53 to 0.76)

8

70.4

55.0

68

58

1.56

0.54

Day 7

0.75 (0.65 to 0.85)

7

59.6

83.0

78

67

3.50

0.49

0.75 (0.65 to 0.85)

7

61.0

79.2

69

72

2.94

0.49

0.71 (0.60 to 0.81)

6

66.7

65.0

72

59

1.91

0.51

SAPS II

                        

Day 1

0.51 (0.39 to 0.62)

49

56.0

48.0

52

52

1.08

0.92

0.63 (0.52 to 0.74)

51

61.4

60.7

55

67

1.56

0.64

0.58 (0.47 to 0.70)

49

60.3

54.8

65

50

1.33

0.72

  1. a95% CI, 95% confidence interval; LR+, positive likelihood ratio; LR-, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; Simplified Acute Physiology Score II score, Sequential Organ Failure Assessment score. The areas under the receiver operating characteristic curve (AUCs) are shown as means (95% confidence intervals).
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