Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial

Table 2 Univariate and multivariate Cox models for mortality ^a

Time	Biomarker	ICU mortality				28-day mortality				90-day mortality
		Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate
Day 1	Presepsin	1.65 (1.22 to 2.24)	0.001	1.51 (1.05 to 2.17)	0.03	1.73 (1.32 to 2.27)	<0.0001	1.55 (1.12 to 2.13)	0.008	1.50 (1.18 to 1.92)	0.001	1.28 (0.96 to 1.71)	0.09
Day 1	Procalcitonin	1.01 (0.87 to 1.18)	0.88	0.89 (0.75 to 1.05)	0.15	1.07 (0.92 to 1.25)	0.40	0.97 (0.84 to 1.12)	0.68	1.03 (0.91 to 1.18)	0.63	0.94 (0.83 to 1.06)	0.32
Day 2	Presepsin	1.84 (1.33 to 2.54)	0.0002	1.83 (1.19 to 2.81)	0.006	2.02 (1.49 to 2.75)	<0.0001	1.93 (1.27 to 2.92)	0.002	1.73 (1.31 to 2.28)	0.0001	1.47 (1.02 to 2.12)	0.04
Day 2	Procalcitonin	1.00 (0.86 to 1.16)	0.97	0.82 (0.68 to 0.98)	0.03	1.05 (0.90 to 1.23)	0.54	0.85 (0.70 to 1.02)	0.08	1.06 (0.92 to 1.21)	0.43	0.86 (0.73 to 1.02)	0.08
Day 7	Presepsin	1.77 (1.30 to 2.41)	0.0003	1.83 (1.22 to 2.74)	0.004	2.11 (1.55 to 2.89)	<0.0001	2.13 (1.41 to 3.21)	0.0003	1.84 (1.41 to 2.41)	<0.0001	1.75 (1.23 to 2.48)	0.002
Day 7	Procalcitonin	1.12 (0.93 to 1.33)	0.23	0.97 (0.78 to 1.21)	0.78	1.29 (1.06 to 1.57)	0.01	1.11 (0.87 to 1.42)	0.39	1.25 (1.05 to 1.47)	0.01	1.08 (0.88 to 1.33)	0.46

^aRisk is presented as hazard ratio and 95% confidence interval with an increment of 1 unit after logarithmic transformation of the biomarker concentration. The following covariates, deemed important clinical variables, were considered in the multivariable models: Simplified Acute Physiology Score II score, Sequential Organ Failure Assessment score, serum lactate concentration, mean arterial pressure, central venous oxygen saturation and randomized treatment (albumin vs. crystalloids).

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