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Figure 8 | Critical Care

Figure 8

From: Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis

Figure 8

Correlation of absolute lymphocyte count and apoptosis. A low absolute lymphocyte count (ALC) is a frequent finding in sepsis and correlates with outcome (see Discussion). We examined the relationship between ALC and apoptosis as determined by the Tunel assay. There was no relationship of apoptosis (percent Tunel positive cells) and the ALC in septic patient considered as a whole (A). If the correlation of apoptosis and ALC was restricted to septic patients who had an ALC below the lower limit of normal at Barnes Jewish Hospital (1.2 × 103 lymphocytes/μL blood), there was a correlation such that patients with the lowest ALCs had the highest percent of Tunel + (apoptotic) lymphocytes. (B) There was a statistical correction between ALC and lymphocyte apoptosis in septic patients who had an ALC less than 1.2 × 103 cells/μL blood (the lower limit of normal at our hospital).

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Critical Care

ISSN: 1364-8535