Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis

Table 4 Risk of death in patients with severe condition

Genes	SNP variant	Survivors (n = 91)		Non-survivors (n = 23)		P (one)	P (both)	Risk of death SNP variant
Genes	SNP variant	No.	(%)	No.	(%)	P (one)	P (both)	Risk of death SNP variant
BPI	A	71	78.0	21	91.3	0.077	0.088	Risk
BPI	B	20	22.0	2	8.7	0.077	0.088	Non-risk
BPI; TLR	BA	19	20.9	1	4.3	0.029	0.029	Non-risk
TLR; IL-6	BA	1	1.1	2	8.7	0.055	0.56	Risk
BPI; LBP; TLR	BAA	16	17.6	1	4.3	0.056	0.062	Non-risk
BPI; TLR; IL-6	BAA	7	7.7	0	0	0.098	0.098	Non-risk
LBP; TLR; IL-6	ABA	1	1.1	2	8.7	0.055	0.56	Risk
BPI; LBP; TLR; HSP 70; IL-6	AAAAB	20	22.0	9	39.1	0.055	0.155	Risk
BPI; LBP; TLR; HSP 70; IL-6	AAABB	8	8.8	0	0	0.077	0.077	Non-risk

All single nucleotide polymorphism (SNP) combinations revealing at least 10% level of statistical significance between survivors and non-survivors of severe sepsis, septic shock or multiple organ dysfunction syndromes (MODS) (based on two-sided Fisher’s exact test) are shown. Other SNP combinations did not demonstrate statistically significant differences and are not presented.

ISSN: 1364-8535