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Table 3 Evaluation of sepsis risk based on five SNPs in paediatric patients

From: Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis

   

Control group (n = 529)

Patient group (n = 598)

Patient group with severe condition (n = 114)

 

Genes

SNP* variant

No.

(%)

No.

(%)

Fisher Mid-P

Risk

No.

(%)

Fisher Mid-P

Risk

Associated SNP combinations

BPI + LBP + TLR

AAA

237

43.5

319

53.3

0.005

H

62

54.4

0.071

I

AAB

31

5.9

34

5.7

0.950

I

4

3.5

0.236

I

ABA

58

11.0

87

14.5

0.068

I

23

20.2

0.034

H

ABB

7

1.3

10

1.7

0.721

I

3

2.6

0.308

I

BAA

144

37.8

110

18.4

<0.001

L

17

14.9

0.003

L

BAB

20

3.8

17

2.8

0.361

I

2

1.8

0.224

I

BBA

27

5.1

15

2.5

0.022

L

3

2.6

0.198

I

BBB

5

0.9

6

1.0

0.882

I

0

0

0.188

I

BPI + TLR + IL-6

AAA

69

13.0

127

21.2

<0.001

H

31

27.2

0.003

H

AAB

226

42.7

279

46.7

0.177

I

54

47.4

0.378

I

ABA

7

1.3

21

3.5

0.016

H

1

0.9

0.818

I

ABB

31

5.9

23

3.8

0.109

I

6

5.3

0.745

I

BAA

44

8.3

36

6.0

0.148

I

7

6.1

0.398

I

BAB

127

24.0

89

14.9

<0.001

L

13

11.4

0.001

L

BBA

4

0.8

10

1.7

0.146

I

2

1.8

0.489

I

BBB

21

4.0

13

2.8

0.100

I

0

0

0.008

L

LBP + TLR + IL-6

AAA

102

19.3

134

22.4

0.200

I

32

28.1

0.050

I

AAB

279

52.7

295

49.3

0.245

I

47

41.2

0.027

L

ABA

8

1.5

25

4.2

0.006

H

3

2.6

0.602

I

ABB

43

8.1

26

4.3

0.011

L

3

2.6

0.015

L

BAA

11

2.1

29

4.8

0.012

H

6

5.3

0.206

I

BAB

74

14.0

73

12.2

0.401

I

20

17.5

0.345

I

BBA

3

0.6

6

1.0

0.416

I

0

0

0.278

I

BBB

9

1.7

10

1.7

0.909

I

3

2.6

0.596

I

Non-associated SNP combination

BPI + HSP 70

AA

212

40.1

323

54.0

<0.001

H

63

55.3

0.004

H

AB

121

22.9

127

21.2

0.494

I

29

25.4

0.585

I

BA

143

27.0

97

16.2

<0.001

L

11

9.6

<0.001

L

BB

53

10.0

51

8.5

0.382

I

11

9.6

0.932

I

All SNPs in combination

BPI + LBP + TLR + HSP 70 + IL-6

AAAAA

36

6.8

70

11.7

0.005

H

13

11.4

0.157

I

AAAAB

111

21.0

162

27.1

0.016

H

29

25.4

0.354

I

AABBB

14

3.6

3

0.5

0.004

L

1

0.9

0.172

I

ABAAA

6

1.1

22

3.7

0.005

H

5

4.4

0.133

I

BAAAB

70

13.2

48

8.0

0.006

L

4

3.5

0.001

L

BABAB

15

2.8

7

1.2

0.041

L

0

0

0.026

L

BBAAB

20

3.8

8

1.3

0.009

L

2

1.8

0.224

I

others

257

48.6

278

46.5

0.492

I

60

52.6

0.440

I

  1. Single nucleotide polymorphisms’ (SNPs’) frequencies and their sepsis risk evaluation for three sets of associated genes, non-associated genes and five gene SNPs.
  2. SNP variants indicate the wild-type (most frequent) homozygote with label “A”, while heterozygote or minor homozygotes are shown as “B”. SNP variants are stated in the same order as genes.
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Critical Care

ISSN: 1364-8535