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Table 2 General hemodynamics

From: Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine study

 

Control

  Metabolic acidosis

Respiratory acidosis

 

Baselinest

Baselineend

Δ

Baseline

Acidosis

Δ

Baseline

Acidosis

Δ

HR

101 ± 20

119 ± 39

 

93 ± 12

161 ± 56

99 ± 25

200 ± 42

SV

44.8 ± 8.7

44.2 ± 18.4

 

51.6 ± 11.9

34.1 ± 13.4

48.2 ± 17.4

35.2 ± 8.4

GEDV

660.4 ± 116.2

691.1 ± 123.6

 

620.3 ± 136.6

571.8 ± 125.1

 

709.1 ± 152.9

693.7 ± 113.6

 

CO

4.5 ± 0.8

4.8 ± 1.2

 

4.8 ± 1.1

5.3 ± 2.0

 

4.5 ± 1.1

7.3 ± 1.8

MAP

94.5 ± 15.6

97.3 ± 16.9

 

87.4 ± 15.3

99.7 ± 18.4

 

88.7 ± 5.6

105.6 ± 9.4

CVP

11.1 ± 2.1

10.6 ± 2.6

 

9.0 ± 2.6

9.3 ± 2.4

 

12.1 ± 3.8

12.1 ± 1.1

 

MPAP

25.1 ± 5.2

26.1 ± 3.9

 

23.1 ± 3.1

42.9 ± 8.4

24.4 ± 1.7

40.3 ± 6.7

PCWP

9.5 ± 1.9

9.3 ± 2.4

 

7.9 ± 2.5

9.3 ± 2.7

 

10.9 ± 1.2

9.3 ± 2.4

 

SVR

1,539 ± 409

1,520 ± 489

 

1,350 ± 327

1,564 ± 729

 

1,412 ± 327

1,068 ± 209

PVR

287 ± 71

301 ± 142

 

268 ± 92

591 ± 283

259 ± 60

356 ± 116

ITBV

825.5 ± 145.3

863.9 ± 154.5

 

796 ± 173.3

715.9 ± 168.9

886.4 ± 191.1

867.1 ± 142

 

LVSW

59.5 ± 17.2

52.8 ± 20

 

61.8 ± 17.9

45.6 ± 18

 

58.4 ± 24.9

55.4 ± 12.4

 

LVSWtot

6,056 ± 1,606

6,183 ± 1,783

 

5,784 ± 1,924

7,179 ± 2,835

 

5,788 ± 1,368

11,124 ± 2,968

RVSW

15.5 ± 4.5

13.7 ± 4.5

 

16.3 ± 5.6

20.4 ± 10.8

 

16.7 ± 7.9

21.1 ± 7.3

 

RVSWtot

1,606 ± 541

1,618 ± 419

 

1,492 ± 420

3,088 ± 1,414

1,650 ± 539

4,166 ± 1,313

HVSW

7,662 ± 2,041

7,801 ± 2,146

 

7,276 ± 2,201

10,267 ± 4,086

 

7,438 ± 1,874

15,290 ± 4,135

Hearte

417.6 ± 111.2

425.2 ± 117

 

396.6 ± 120

559.6 ± 222.7

 

405.4 ± 102.1

833.4 ± 225.4

  1. ↑, significantly increased, P < 0.05; ↓, significantly decreased, P < 0.05; HR, heart rate (bpm); SV, stroke volume (ml); GEDV, global end-diastolic volume (ml); CO, cardiac output (L/min); MAP, mean arterial pressure (mm Hg); CVP, central venous pressure (mm Hg); MPAP, mean pulmonary artery pressure (mm Hg); PCWP, pulmonary capillary wedge pressure (mm Hg); SVR, systemic vascular resistance (dyne s/cm-5); PVR, pulmonary vascular resistance (dyne s/cm-5); ITBV, intrathoracic blood volume (ml); LVSW, left ventricular stroke work (cJ), calculated as 0.0136 × MAP × SV; LVSWtot, left ventricular stroke work per minute (cJ/min); RVSW, right ventricular stroke work (cJ), calculated as 0.0136 × MPAP × SV; RVSWtot, right ventricular stroke work per minute (cJ/min); HVSW, (complete) heart ventricular stroke work per minute (cJ/min); heartE, heart energy (kcal).