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Table 5 Effects of antithrombin on platelet counts, coagulation and fibrinolysis

From: A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis

 

Control (n)

Antithrombin (n)

Pvalue

SIRS

 Day 0

3.0 ± 1.0 (29)

3.0 ± 0.9 (30)

0.996

 Day 3

1.6 ± 1.2 (28)

1.9 ± 1.2 (30)

0.414

Platelet (109/L)

 Day 0

82.5 ± 51.8 (30)

95.4 ± 55.2 (30)

0.355

 Day 3

68.9 ± 45.5 (28)

106.9 ± 85.5 (30)

0.041

Prothrombin time (INR)

 Day 0

1.5 ± 1.3 (30)

1.4 ± 0.2 (30)

0.531

 Day 3

1.2 ± 0.6 (28)

1.2 ± 0.3 (30)

0.955

Fibrinogen (g/L)

 Day 0

4.62 ± 2.63 (30)

4.26 ± 1.66 (30)

0.542

 Day 3

4.57 ± 1.28 (28)

4.41 ± 1.70 (28)

0.688

FDP (mg/L)

 Day 0

31.2(13.6-85.1) (30)

25.95(14.2-48.6) (30)

0.620

 Day 3

18.6(10.0-43.6) (28)

14.65(8.2-20.7) (28)

0.065

  1. Values of FDP are median (25% quartile to 75% quartile). SIRS, systemic inflammatory response syndrome; INR, international normalized ratio; FDP, fibrin/fibrinogen degradation products.