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Table 5 Effects of antithrombin on platelet counts, coagulation and fibrinolysis

From: A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis

  Control (n) Antithrombin (n) Pvalue
SIRS
 Day 0 3.0 ± 1.0 (29) 3.0 ± 0.9 (30) 0.996
 Day 3 1.6 ± 1.2 (28) 1.9 ± 1.2 (30) 0.414
Platelet (109/L)
 Day 0 82.5 ± 51.8 (30) 95.4 ± 55.2 (30) 0.355
 Day 3 68.9 ± 45.5 (28) 106.9 ± 85.5 (30) 0.041
Prothrombin time (INR)
 Day 0 1.5 ± 1.3 (30) 1.4 ± 0.2 (30) 0.531
 Day 3 1.2 ± 0.6 (28) 1.2 ± 0.3 (30) 0.955
Fibrinogen (g/L)
 Day 0 4.62 ± 2.63 (30) 4.26 ± 1.66 (30) 0.542
 Day 3 4.57 ± 1.28 (28) 4.41 ± 1.70 (28) 0.688
FDP (mg/L)
 Day 0 31.2(13.6-85.1) (30) 25.95(14.2-48.6) (30) 0.620
 Day 3 18.6(10.0-43.6) (28) 14.65(8.2-20.7) (28) 0.065
  1. Values of FDP are median (25% quartile to 75% quartile). SIRS, systemic inflammatory response syndrome; INR, international normalized ratio; FDP, fibrin/fibrinogen degradation products.