Figure 6

Bacterial outgrowth in Receptor for advanced glycation end products ( Rage )^−/−mice is reduced early after intranasal infection with S. aureus . Bacterial loads after intranasal infection with 1 × 10⁷ colony-forming units (CFU) S. aureus in bronchiolar lavage (BAL) fluid (A) of mice treated with control (gray) and anti-HMGB1 antibodies (white) and in BAL fluid (B) of Wt (dark gray), Toll-like receptor (tlr)4^−/− (light gray) and rage^−/− mice (white) at 6, 24, 48 and 72 hours after infection. Data are expressed as box-and-whisker diagrams depicting the median, the smallest observation, lower quartile, median, upper quartile and largest observation (n = 7 to 8 mice per group at each time point). ^**P <0.01 versus Wt mice at the same time point.