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Figure 5 | Critical Care

Figure 5

From: High-mobility group box 1 and the receptor for advanced glycation end products contribute to lung injury during Staphylococcus aureus pneumonia

Figure 5

Receptor for advanced glycation end products ( Rage )−/−mice show lower levels of TNF-α and IL-6 in bronchiolar lavage (BAL) fluid during S. aureus pneumonia. Cytokine (TNF-α, IL-6 and IL-1β) (A-C) and chemokine (keratinocyte-derived chemokine (KC) and macrophage inflammatory protein (MIP)-2) (D-E) levels 6, 24, 48 and 72 hours after intranasal S. aureus infection in Wt (dark gray) and tlr4−/− (light gray) and rage−/− mice (white). Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation (7 to 8 mice per group at each time point). *P <0.05, **P <0.01 versus Wt mice.

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