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Figure 4 | Critical Care

Figure 4

From: High-mobility group box 1 and the receptor for advanced glycation end products contribute to lung injury during Staphylococcus aureus pneumonia

Figure 4

Anti-high mobility group box 1 (HMGB1) treatment reduces IL-1β and keratinocyte-derived chemokine (KC) levels in bronchiolar lavage (BAL) fluid after intranasal infection with S. aureus. Cytokine (TNF-α, IL-6 and IL-1β) (A-C) and chemokine (KC and macrophage inflammatory protein (MIP)-2) (D-E) levels in BAL fluid at different time points after intranasal infection of 1 × 107 colony-forming units (CFU) S. aureus in mice treated with control (gray) and anti-HMGB1 antibodies (white). Data are expressed as box-and-whisker diagrams depicting the median, the smallest observation, lower quartile, median, upper quartile and largest observation (7 to 8 mice per group at each time point). *P <0.05, **P <0.01 versus Wt mice at the same time point.

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Critical Care

ISSN: 1364-8535