Variable | Group 1, H-H | Group 2, L-H | Group 3, H-L | Group 4, L-L | P value |
---|---|---|---|---|---|
(n= 24) | (n= 8) | (n= 17) | (n= 36) | ||
Hemodynamic variables | |||||
Heart rate (beats/minute) | |||||
T0 | 112 (103 to 129) | 111 (77 to 138) | 104 (86 to 126) | 109 (93 to 118) | 0.31 |
T6 | 114 (101 to 125) | 103 (73 to 127) | 98 (85 to 114) | 103 (88 to 118) | 0.14 |
Cardiac index (l/minute/m2) | |||||
T0 | 3.0 (2.3 to 4.2) | 3.6 (2.7 to 4.6) | 3.0 (2.5 to 5.0) | 3.5 (2.7 to 4.5) | 0.63 |
T6 | 3.2 (2.2 to 4.3) | 3.3 (2.4 to 3.8) | 3.7 (2.2 to 5.5) | 3.6 (2.8 to 4.3) | 0.75 |
MAP (mmHg) | |||||
T0 | 65.0 (61.0 to 72.8)** | 67.0 (65.3 to 69.5) | 73.0 (68.0 to 82.5)** | 72.0 (64.5 to 77.0) | 0.02 |
T6 | 69.0 (65.3 to 75.8) | 77.5 (70.5 to 96.0) | 68.0 (63.5 to 72.0) | 71.5 (65.0 to 78.8) | 0.06 |
CVP (mmHg) | |||||
T0 | 14.5 (10.3 to 17.0) | 10.0 (9.0 to 12.8) | 12.0 (8.5 to 15.0) | 10.0 (7.0 to 14.0) | 0.10 |
T6 | 13.5 (10.0 to 15.8)** | 15.0 (10.0 to 17.0) | 10.0 (5.0 to 12.5)** | 10.0 (7.3 to 13.0) | 0.03 |
PAOP (mmHg) | |||||
T0 | 17.0 (14.0 to 20.0) | 12.5 (10.0 to 15.0) | 17.0 (12.0 to 22.0) | 15.0 (11.0 to 20.0) | 0.52 |
T6 | 19.0 (15.0 to 24.0)** | 14.5 (10.0 to 19.0) | 13.0 (10.0 to 15.0)** | 16.0 (12.0 to 20.0) | 0.03 |
Blood gases and oxygen variables | |||||
pH | |||||
T0 | 7.30 (7.18 to 7.37) | 7.31 (7.22 to 7.40) | 7.34 (7.22 to 7.41) | 7.32 (7.24 to 7.40) | 0.85 |
T6 | 7.32 (7.20 to 7.36) | 7.35 (7.30 to 7.42) | 7.35 (7.26 to 7.39) | 7.34 (7.30 to 7.39) | 0.33 |
PaCO2 (mmHg) | |||||
T0 | 30.5 (24.1 to 36.6) | 34.2 (24.7 to 36.9) | 31.0 (23.6 to 33.6) | 27.5 (23.7 to 36.5) | 0.81 |
T6 | 26.1 (22.4 to 32.7) | 31.0 (21.6 to 34.0) | 31.3 (26.8 to 33.6) | 27.5 (21.7 to 32.1) | 0.25 |
PvmCO2 (mmHg) | |||||
T0 | 40.6 (33.9 to 46.5)¶ | 29.5 (25.0 to 35.3) | 39.7 (35.5 to 47.1) 34.3 | 32.8 (27.3 to 40.9)¶ | 0.03 |
T6 | 38.0 (29.9 to 39.7)¶ | 38.3 (28.0 to 46.2) | (30.4 to 36.8) | 30.0 (25.5 to 35.5)¶ | 0.02 |
PvcCO2 (mmHg) | |||||
T0 | 38.2 (29.1 to 50.5) | 40.1 (34.2 to 43.4) | 36.7 (35.5 to 47.1) 33.9 | 32.5 (28.1 to 38.4) | 0.12 |
T6 | 33.7 (28.3 to 36.9) | 33.8 (31.4 to 41.4) | (30.4 to 36.8) | 29.0 (25.1 to 35.8) | 0.20 |
PaO2 (mmHg) | |||||
T0 | 112.2 (79.3 to 167.3) | 117.1 (77.5 to 139.5) | 115.7 (81.4 to 140.8) | 100 (86.0 to 123.9) | 0.70 |
T6 | 113.6 (83.0 to 147.3) | 132.5 (109.8 to 197.8) | 105.0 (83.5 to 127.4) | 111.5 (86.2 to 135.7) | 0.34 |
PaO2/FiO2 (mmHg) | |||||
T0 | 188.9 (117.1 to 265.0) | 166.9 (143.8 to 244.1) | 233.7 (184.6 to 314.0) | 214.3 (141.6 to 368.0) | 0.28 |
T6 | 177.9 (136.4 to 298.4) | 265.0 (185.5 to 383.5) | 239.3 (185.1 to 306.3) | 253.5 (181.6 to 368.0) | 0.17 |
Lactate (mmol/l) | |||||
T0 | 4.3 (2.0 to 7.9) | 2.9 (2.0 to 9.7) | 2.7 (1.5 to 3.9) | 2.9 (1.7 to 4.7) | 0.16 |
T6 | 3.3 (2.1 to 6.8)**¶ | 2.9 (1.1 to 7.1) | 1.3 (0.9 to 2.3)** | 2.0 (1.0 to 3.5)¶ | 0.002 |
ScvO2 (%) | |||||
T0 | 64.0 (54.7 to 75.1) | 66.8 (59.7 to 74.5) | 73.0 (70.8 to 76.7) | 67.1 (62.1 to 75.9) | 0.36 |
T6 | 70.8 (66.4 to 73.5) | 73.4 (69.3 to 78.0) | 72.3 (67.2 to 75.9) | 76.0 (60.0 to 77.9) | 0.53 |
SvO2 (%) | |||||
T0 | 66.0 (56.8 to 71.4) | 68.0 (54.9 to 81.0) | 68.1 (57.0 to 71.0) | 69.7 (62.1 to 75.9) | 0.39 |
T6 | 69.0 (63.3 to 72.9) | 70.6 (63.4 to 73.8) | 71.2 (64.4 to 75.1) | 68.0 (58.7 to 74.3) | 0.77 |
Oxygen extraction ratio | |||||
T0 | 34.7 (28.3 to 44.3) | 30.8 (22.7 to 38.4) | 29.4 (25.0 to 36.8) | 30.7 (24.9 to 37.5) | 0.36 |
T6 | 29.8 (26.4 to 36.6) | 30.2 (24.9 to 31.3) | 29.3 (24.1 to 33.3) | 30.7 (23.4 to 39.3) | 0.68 |
Pv-aCO2 (mmHg) | |||||
T0 | 8.2 (7.0 to 10.6)*¶ | 1.4 (1.1 to 5.3)*φ | 6.3 (6.1 to 7.2)φξ | 2.7 (2.0 to 4.0)¶ ξ | <0.001 |
T6 | 7.6 (6.4 to 9.4)**¶ | 8.6 (6.5 to 11.7)φΨ | 3.5 (0.9 to 4.3)**φ | 3.3 (2.2 to 4.1)¶ Ψ | <0.001 |
Pvc-aCO2 (mmHg) | |||||
T0 | 9.7 (7.0 to 12.1)¶ | 4.6 (3.3 to 6.1) | 7.3 (4.6 to 9.1) | 4.4 (2.7 to 5.4)¶ | <0.001 |
T6 | 7.0 (5.8 to 9.7) | 8.5 (5.6 to 9.6)Ψ | 4.4 (2.1 to 5.5) | 4.0 (1.7 to 5.4)Ψ | 0.003 |
Ventilatory parameters | |||||
Mechanical ventilation | |||||
T0 | 24 | 5 | 11 | 23 | 0.01 |
T6 | 24 | 5 | 11 | 23 | 0.01 |
PEEP (mmHg), n | 5.0 (5.0 to 8.0), 11 | 6.0 (5.0 to 8.0), 23 | 0.48 | ||
T0 | 6.0 (5.0 to 8.0), 24 | 5.0 (5.0 to 6.0), 5 | 5.0 (5.0 to 8.0), 11 | 8.0 (5.0 to 10.0), 23 | |
T6 | 6.5 (5.0 to 8.0), 24 | 5.0 (5.0 to 7.5), 5 | |||
Tidal volume (ml/kg) | |||||
T0 | 7.1 (6.3 to 7.7) | 7.3 (6.3 to 7.6), 5 | 7.0 (6.5 to 8.0), 11 | 7.5 (6.6 to 8.0), 23 | 0.65 |
T6 | 7.2 (6.3 to 7.9) | 7.2 (6.6 to 7.6), 5 | 7.5 (6.8 to 8.0), 11 | 7.5 (6.9 to 8.0), 23 | 0.65 |