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Table 2 Patients’ demographic and clinical characteristics of septic patients

From: Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients

  Survival (n = 215) Non-survival (n = 113) P-value
Gender male – n (%) 146 (67.9) 73 (64.6) 0.62
Age - median years (p 25 to 75) 59 (47 to 69) 65 (56 to 74) 0.001
Diabetes mellitus - n (%) 54 (25.1) 45 (39.8) 0.008
Chronic renal failure - n (%) 13 (6.0) 14 (12.4) 0.06
COPD - n (%) 32 (14.9) 16 (14.2) 0.99
Ischemic heart disease - n (%) 24 (11.2) 12 (10.6) 0.99
Site of infection - n (%)    0.94
 ·Respiratory 122 (56.7) 63 (55.8)  
  ·Abdominal 59 (27.4) 32 (28.3)  
 ·Neurological 5 (2.3) 1 (0.9)  
 ·Urinary 12 (5.6) 6 (5.3)  
 ·Skin 10 (4.7) 5 (4.4)  
 ·Endocarditis 6 (2.8) 5 (4.4)  
 ·Osteomyelitis 1 (0.5) 1 (0.9)  
Microorganisms responsible - n (%)    0.89
 ·Unknown 114 (53.0) 61 (54.0)  
 ·Gram-positive 51 (23.7) 27 (23.9)  
 ·Gram-negative 50 (23.3) 24 (21.2)  
 ·Fungii 4 (1.9) 4 (3.5)  
 ·Anaerobe 2(0.9) 1 (0.9)  
Bloodstream infection - n (%) 29 (13.5) 18(15.9) 0.62
Empiric antimicrobial treatment adequate - n (%)    0.76
 ·Unknown due to negative cultures 114 (53.0) 62 (54.9)  
 ·Adequate 84 (39.1) 44 (38.9)  
 ·Unknown due to antigenuria diagnosis 4 (1.9) 3 (2.7)  
 ·Inadequate 13 (6.0) 4 (3.5)  
Betalactamic more aminoglycoside - n (%) 45 (20.9) 27 (23.9) 0.57
Betalactamic more quinolone - n (%) 111 (51.6) 56 (49.6) 0.73
Pa02/FI02 ratio - median (p 25 to 75) 183 (127 to 271) 169 (102 to 240) 0.11
Creatinine (mg/dl) - median (p 25 to 75) 1.30 (0.80 to 2.10) 1.63 (1.00 to 2.95) 0.009
Bilirubin (mg/dl) - median (p 25 to 75) 0.87 (0.50 to 1.40) 0.93 (0.50 to 2.17) 0.28
Leukocytes - median*103/mm3 (p 25 to 75) 14.6 (9.2 to 19.4) 14.9 (6.8 to 20.4) 0.72
Lactic acid - median mmol/L (p 25 to 75) 2.00 (1.10 to 3.40) 3.55 (1.60 to 6.00) <0.001
Platelets - median*103/mm3 (p 25 to 75) 195 (131 to 269) 132 (67 to 224) <0.001
INR - median (p 25 to 75) 1.25 (1.10 to 1.50) 1.42 (1.15 to 1.90) 0.002
aPTT - median seconds (p 25 to −75) 32 (28 to 39) 36 (29 to 46) 0.005
SOFA score - median (p 25 to 75) 9 (7 to 11) 11 (9 to 15) <0.001
APACHE-II score - median (p 25 to 75) 19 (15 to 23) 23 (19 to 29) <0.001
MDA - median nmol/mL (p 25 to 75) 2.35 (1.62 to 3.81) 3.71 (1.65 to 4.56) <0.001
  1. APACHE-II, Acute Physiology and Chronic Health Evaluation-II; aPTT, Activated partial thromboplastin time; COPD, chronic obstructive pulmonary disease; INR, International normalized ratio; PaO2/FIO2, pressure of arterial oxygen/fraction of inspired oxygen; SOFA, Sepsis-related Organ Failure Assessment; data are presented as number (percentage) or median (interquartile range); Labwork was made at first day.