| Univariate | Multivariate |
---|
|
P
| Odds ratio (95% CI) |
P
|
---|
mHLA-DR
| <0.0001 | 7.8 (2.6 to 23.4) | <0.0001 |
SOFA
| 0.011 | 3.3 (1.1 to 10.2) | 0.034 |
SAPS II
| 0.013 | 1.7 (0.6 to 5.1) | 0.341 |
CD74
| 0.006 | 3.4 (1.2 to 9.8) | 0.026 |
SOFA
| 0.011 | 2.3 (0.8 to 6.4) | 0.106 |
SAPS II
| 0.013 | 2.1 (0.7 to 5.8) | 0.166 |
- Major histocompatibility class II-related gene mRNA levels and circulating monocyte HLA-DR expression (mHLA-DR) were measured in blood samples obtained from 93 septic shock patients at Day 3 or Day 4 after the onset of shock. Uni- and multi-variate logistic regression analyses were used to identify the variables associated with death (n = 66 survivors and 27 non-survivors) and Cox model permitted to estimate the Hazard Ratio and 95% confidence interval (CI 95%). Backward selection was used and a P-value of 0.05 was considered as statistically significant. Because SAP II and SOFA confirmed the assumed linearity with the outcome (survivors vs non-survivors), these variables were included in the model as continuous variables. CD74, HLA-DR antigen-associated invariant chain; HLA-DR, human leukocyte antigen-DR/DM; SAPS II, Simplified Acute Physiologic Score II calculated at inclusion in the protocol; SOFA score, Sequential Organ Failure Assessment score measured after 24 h of ICU stay.