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Table 4 Multivariate analysis

From: Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock

 

Univariate

Multivariate

 

P

Odds ratio (95% CI)

P

mHLA-DR

<0.0001

7.8 (2.6 to 23.4)

<0.0001

SOFA

0.011

3.3 (1.1 to 10.2)

0.034

SAPS II

0.013

1.7 (0.6 to 5.1)

0.341

CD74

0.006

3.4 (1.2 to 9.8)

0.026

SOFA

0.011

2.3 (0.8 to 6.4)

0.106

SAPS II

0.013

2.1 (0.7 to 5.8)

0.166

  1. Major histocompatibility class II-related gene mRNA levels and circulating monocyte HLA-DR expression (mHLA-DR) were measured in blood samples obtained from 93 septic shock patients at Day 3 or Day 4 after the onset of shock. Uni- and multi-variate logistic regression analyses were used to identify the variables associated with death (n = 66 survivors and 27 non-survivors) and Cox model permitted to estimate the Hazard Ratio and 95% confidence interval (CI 95%). Backward selection was used and a P-value of 0.05 was considered as statistically significant. Because SAP II and SOFA confirmed the assumed linearity with the outcome (survivors vs non-survivors), these variables were included in the model as continuous variables. CD74, HLA-DR antigen-associated invariant chain; HLA-DR, human leukocyte antigen-DR/DM; SAPS II, Simplified Acute Physiologic Score II calculated at inclusion in the protocol; SOFA score, Sequential Organ Failure Assessment score measured after 24 h of ICU stay.