Figure 2

Prognostic value of mHLA-DR and CD74 mRNA levels in septic shock patients. CD74 mRNA level and circulating monocyte HLA-DR expression (mHLA-DR) were measured in blood samples obtained from 93 septic shock patients at Day 3 or Day 4 after the onset of shock. A). Receiver operating characteristic curves were established for these two parameters. The area under the curve was 0.67 for CD74 (95% confidence interval (95% CI): 0.55 to 0.79; P = 0.01) and 0.70 (95% CI: 0.57 to 0.83; P = 0.003) for mHLA-DR. B). Kaplan-Meier survival curves were established after stratification based on CD74 mRNA level cut-off value (= 0.185, optimized Youden index). A significant difference was measured between the two curves (Log rank test, P = 0.0043; Hazard Ratio = 3.0, 95% CI: 1.4 to 6.5). C). Similar analysis was performed for mHLA-DR. Cut-off value = 1,662 AB/C. Log rank test: P <0.0001, Hazard Ratio = 5.8, 95% CI = 2.6 to 12.9.