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Figure 6 | Critical Care

Figure 6

From: Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+macrophages

Figure 6

Effects of galectin (Gal)-9 on splenic macrophages and dendritic cells (DCs). Spleen cells were obtained from PBS- or Gal-9 treated cecal ligation and puncture (CLP) mice at 24 hours after a single intravenous injection and stained with F4/80, PDCA-1, CD11c and Tim-3. (A) An increased frequency of plasmacytoid (p)DC-like macrophages (F4/80+ PDCA-1+ CD11c+) but not cDCs (F4/80- PDCA-1- CD11c+) was observed; n = 5 for each group (NS, not significant; *P <0.05). (B) High Tim-3 expression on pDC-like macrophages was observed; n = 5 for each group (NS, not significant; ***P <0.001). Blue line, pDC-like macrophages; orange line, cDCs; red line, PDCA-1+ CD11c- cells. (C) Increased Tim-3-expressing pDC-like macrophages in Gal-9-treated CLP mice; n = 5 for each group (NS, not significant; ***P <0.001).

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