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Figure 2 | Critical Care

Figure 2

From: Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+macrophages

Figure 2

Delayed galectin (Gal)-9 treatment prolongs the survival of cecal ligation and puncture (CLP) mice. (A) CLP mice received a single Gal-9 injection (intravenous (i.v.), 30 μg/mouse) immediately after CLP, and survival was monitored for 7 days. The log-rank (Mantel-Cox) test was used for statistical analysis. (B) Bacterial load in peritoneal fluid (PF) in PBS- (n = 14) and Gal-9-treated (n = 13) mice at 24 hours after CLP. PF dilutions were plated on tryptic soy blood agar plates and incubated overnight at 37°C. The number of aerobic colonies was counted (NS, not significant). (C) Therapeutic effects of delayed i.v. Gal-9 injection on septic mice induced by CLP. Gal-9 was injected i.v. at 24 hours after CLP, and survival was monitored for 7 days. The log-rank (Mantel-Cox) test was used for statistical analysis; P <0.05. (D) No therapeutic effects of i.v. Gal-9 injected immediately after CLP in nude mice. The log-rank (Mantel-Cox) test was used for statistical analysis of survival.

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Critical Care

ISSN: 1364-8535