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Figure 1 | Critical Care

Figure 1

From: Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+macrophages

Figure 1

Survival of galectin (Gal)-9 transgenic (TG) mice during polymicrobial sepsis induced by cecal ligation and puncture (CLP). (A) Prolonged survival of Gal-9 TG mice. CLP was performed, and survival was monitored for 7 days after CLP in wild-type (WT) and Gal-9 TG CLP mice. The log-rank (Mantel-Cox) test was used for statistical analysis; P <0.01. (B) Cytokine levels in peritoneal fluids (PF) from WT (n = 18) and Gal-9 TG (n = 19) mice. At 24 hours after CLP, PF was obtained and ELISA was used for quantification of cytokine levels (*P <0.05; NS, not significant). (C) Bacterial load in WT (n = 11) and Gal-9 TG (n = 8) mice. PF dilutions were plated on tryptic soy blood agar plates and incubated overnight at 37°C. The number of aerobic colonies was counted.

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