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Figure 7 | Critical Care

Figure 7

From: Optimal dosing of antibiotics in critically ill patients by using continuous/extended infusions: a systematic review and meta-analysis

Figure 7

Effects of pharmacodynamic-based antibiotic dosing on mortality comparing continuous with extended-infusion subgroups. The continuous-infusion studies included nine RCTs [15–22, 29] and two cohort studies [31, 34], whereas the extended-infusion studies included only cohort studies. Individual-study RRs with 95% CIs are shown as squares with lines, and pooled RRs with 95% CIs, calculated by using random-effects models both overall and separately for each subgroup, are shown as diamonds. The interaction P value, calculated by using a Z test, testing for subgroup differences between continuous and extended infusion studies, did not achieve statistical significance (P = 0.12). Weight refers to the weighting of each individual study to the overall pooled RR. CI, confidence interval; IV, inverse variance; RCT, randomized controlled trial; RR, relative risk.

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Critical Care

ISSN: 1364-8535