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Figure 5 | Critical Care

Figure 5

From: Optimal dosing of antibiotics in critically ill patients by using continuous/extended infusions: a systematic review and meta-analysis

Figure 5

Effects of pharmacodynamic-based antibiotic dosing on hospital length of stay, grouped by RCT versus cohort studies. Individual study RRs with 95% CIs are shown as squares with lines, and pooled RRs with 95% CI, calculated by using random-effects models both overall and separately for each subgroup, are shown as diamonds. Z tests were used to test for subgroup differences. Ranges [25] or IQR [22, 36, 37] converted to standard deviations by using the methods of Hozo [10] or by dividing by 1.35, as previously described [11], respectively, or standard deviations calculated from reported 95% confidence intervals assuming equal standard deviations between groups [30]. Weight refers to the weighting of each individual study to the overall pooled RR. CI, confidence interval; IV, inverse variance; RCT, randomized controlled trial; SD, standard deviation; IQR, interquartile range.

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Critical Care

ISSN: 1364-8535