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Figure 4 | Critical Care

Figure 4

From: Optimal dosing of antibiotics in critically ill patients by using continuous/extended infusions: a systematic review and meta-analysis

Figure 4

Effects of pharmacodynamic-based antibiotic dosing on ICU length of stay, grouped by RCT versus cohort studies. Individual study RRs with 95% CIs are shown as squares with lines, and pooled RRs with 95% CI, calculated by using random-effects models both overall and separately for each subgroup, are shown as diamonds. Z tests were used to test for subgroup differences. IQR [22, 29, 35, 36] converted to standard deviations by dividing by 1.35, as previously described [11], or standard deviations calculated from reported 95% CIs, assuming equal standard deviations between groups [30]. Weight refers to the weighting of each individual study to the overall pooled RR. CI, confidence interval; IV, inverse variance; RCT, randomized controlled trial; SD, standard deviation; IQR, interquartile range.

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Critical Care

ISSN: 1364-8535