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Table 2 CD4 + T cells (CD3 + , CD4 + , FOXP3 – ) gained BTLA expression (MFI) 72 hours following CLP surgery

From: B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients

 

Sham mice (n = 6)

CLP mice (n = 10)

P value

Blood – 24 hours post surgery

   

 % BTLA+ (SEM)

96.72 (0.65)

93.36 (0.88)

0.01

 BTLA MFI (SEM)

11.91 (1.07)

10.00 (0.41)

NS

Blood – 72 hours post surgery

   

 % BTLA+ (SEM)

95.80 (1.41)

94.34 (1.70)

NS

 BTLA MFI (SEM)

8.79 (0.48)

12.10 (0.66)

0.02

Spleen – 24 hours post surgery

   

 % BTLA+ (SEM)

97.67 (0.27)

97.29 (0.50)

NS

 BTLA MFI (SEM)

10.89 (0.20)

10.73 (0.76)

NS

Spleen – 72 hours post surgery

   

 % BTLA+ (SEM)

98.44 (0.36)

98.23 (0.90)

NS

 BTLA MFI (SEM)

7.43 (0.18)

11.64 (0.64)

<0.01

  1. P value evaluated via an unpaired, two-tailed Student’s t test ± standard error of the mean (SEM); bold values are significant. Mean fluorescent intensity (MFI) experiments were conducted with three to five mice for each group and then repeated for confirmation of the results. BTLA, B and T lymphocyte attenuator; CLP, cecal ligation and puncture; NS, not significant.