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Table 2 CD4 + T cells (CD3 + , CD4 + , FOXP3 ) gained BTLA expression (MFI) 72 hours following CLP surgery

From: B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients

  Sham mice (n = 6) CLP mice (n = 10) P value
Blood – 24 hours post surgery    
 % BTLA+ (SEM) 96.72 (0.65) 93.36 (0.88) 0.01
 BTLA MFI (SEM) 11.91 (1.07) 10.00 (0.41) NS
Blood – 72 hours post surgery    
 % BTLA+ (SEM) 95.80 (1.41) 94.34 (1.70) NS
 BTLA MFI (SEM) 8.79 (0.48) 12.10 (0.66) 0.02
Spleen – 24 hours post surgery    
 % BTLA+ (SEM) 97.67 (0.27) 97.29 (0.50) NS
 BTLA MFI (SEM) 10.89 (0.20) 10.73 (0.76) NS
Spleen – 72 hours post surgery    
 % BTLA+ (SEM) 98.44 (0.36) 98.23 (0.90) NS
 BTLA MFI (SEM) 7.43 (0.18) 11.64 (0.64) <0.01
  1. P value evaluated via an unpaired, two-tailed Student’s t test ± standard error of the mean (SEM); bold values are significant. Mean fluorescent intensity (MFI) experiments were conducted with three to five mice for each group and then repeated for confirmation of the results. BTLA, B and T lymphocyte attenuator; CLP, cecal ligation and puncture; NS, not significant.