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Table 2 Severity of disease at presentation and outcome according to the number of hemostatic abnormalities in 72 patients with septic shock

From: The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation

Median (IQR) or number (%) Group 1, n = 28 (no DIC or ADAMTS13 activity >30%a) Group 2, n = 33 (either DIC or ADAMTS13 activity <30%a) Group 3, n = 11 (both DIC and ADAMTS13 activity <30%a) P-value
ISTH score 3 (2, 4) 3 (2, 5) 5 (5, 7) 0.01
ADAMTS13 activity 46% (39, 79) 24% (19, 54) 15% (9, 25) 0.002
Severity of disease     
LOD score, day 1 7 (4, 9) 7 (6, 10) 13 (7, 14) 0.02
SAPS II score, day 1 48 (38, 65) 62 (47, 69) 77 (51, 95) 0.01
Systolic blood pressure, mmHg 85 (80, 91) 80 (67, 86) 72 (67, 76) 0.004
PaO/FiO2 240 (116, 300) 140 (110, 245) 95 (76, 127) 0.02
Lactates, mmol/L 2.6 (2.0, 5.6) 3 (1.9, 6.3) 6.4 (1.9, 16.5) 0.06
IL-6 concentration, pg/mL 78 (46, 126) 318 (94, 1003) 1,835 (500, 3,030) 0.004
Outcome     
Need for mechanical ventilation 19 (68) 26 (79) 10 (91) 0.25
Persistent shock, day 3 10 (35.7) 26 (79) 11 (100) 0.001
Need for RRT 8 (28.6) 10 (30.3) 5 (45.3) 0.24
Continuous hemofiltration 2 (7.1) 6 (18.2) 4 (36.3) 0.09
Dotrecogrin alpha activated 2 (7.1) 0 0 0.19
Stress dose steroids 6 (21.4) 6 (18.2) 1 (9) 0.64
Length of ICU stay 5 (3, 13) 5 (3, 13) 6 (2, 15) 0.95
ICU mortality 6 (21.4) 18 (54.5) 5 (45.4) 0.02
Hospital mortality 28.6% 71% 75% 0.007
  1. Values are expressed as median and IQR for continuous variables and as proportion for categorical variables. Continuous variables were compared using the non-parametric Kruskall-Wallis test. Categorical variables were compared using thea χ2 test. P <0.05 was considered significant. The normal range for ADAMTS13 activity is 50 to 150%. a30% corresponds to the median of ADAMTS13 activity in the 72 patients with septic shock. DIC, disseminated intravascular coagulation; ISTH: International Society for Thrombosis and Haemostasis; ADAMTS13, a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13; LOD, logistic organ dysfunction; SAPS II, Simplified Acute Physiology Score II; PaO/FiO2, arterial partial pressure of oxygen/inspired oxygen fraction; RRT, renal replacement therapy.