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Table 2 Severity of disease at presentation and outcome according to the number of hemostatic abnormalities in 72 patients with septic shock

From: The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation

Median (IQR) or number (%)

Group 1, n = 28 (no DIC or ADAMTS13 activity >30%a)

Group 2, n = 33 (either DIC or ADAMTS13 activity <30%a)

Group 3, n = 11 (both DIC and ADAMTS13 activity <30%a)

P-value

ISTH score

3 (2, 4)

3 (2, 5)

5 (5, 7)

0.01

ADAMTS13 activity

46% (39, 79)

24% (19, 54)

15% (9, 25)

0.002

Severity of disease

    

LOD score, day 1

7 (4, 9)

7 (6, 10)

13 (7, 14)

0.02

SAPS II score, day 1

48 (38, 65)

62 (47, 69)

77 (51, 95)

0.01

Systolic blood pressure, mmHg

85 (80, 91)

80 (67, 86)

72 (67, 76)

0.004

PaO/FiO2

240 (116, 300)

140 (110, 245)

95 (76, 127)

0.02

Lactates, mmol/L

2.6 (2.0, 5.6)

3 (1.9, 6.3)

6.4 (1.9, 16.5)

0.06

IL-6 concentration, pg/mL

78 (46, 126)

318 (94, 1003)

1,835 (500, 3,030)

0.004

Outcome

    

Need for mechanical ventilation

19 (68)

26 (79)

10 (91)

0.25

Persistent shock, day 3

10 (35.7)

26 (79)

11 (100)

0.001

Need for RRT

8 (28.6)

10 (30.3)

5 (45.3)

0.24

Continuous hemofiltration

2 (7.1)

6 (18.2)

4 (36.3)

0.09

Dotrecogrin alpha activated

2 (7.1)

0

0

0.19

Stress dose steroids

6 (21.4)

6 (18.2)

1 (9)

0.64

Length of ICU stay

5 (3, 13)

5 (3, 13)

6 (2, 15)

0.95

ICU mortality

6 (21.4)

18 (54.5)

5 (45.4)

0.02

Hospital mortality

28.6%

71%

75%

0.007

  1. Values are expressed as median and IQR for continuous variables and as proportion for categorical variables. Continuous variables were compared using the non-parametric Kruskall-Wallis test. Categorical variables were compared using thea χ2 test. P <0.05 was considered significant. The normal range for ADAMTS13 activity is 50 to 150%. a30% corresponds to the median of ADAMTS13 activity in the 72 patients with septic shock. DIC, disseminated intravascular coagulation; ISTH: International Society for Thrombosis and Haemostasis; ADAMTS13, a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13; LOD, logistic organ dysfunction; SAPS II, Simplified Acute Physiology Score II; PaO/FiO2, arterial partial pressure of oxygen/inspired oxygen fraction; RRT, renal replacement therapy.