Median (IQR) or number (%) | Group 1, n = 28 (no DIC or ADAMTS13 activity >30%a) | Group 2, n = 33 (either DIC or ADAMTS13 activity <30%a) | Group 3, n = 11 (both DIC and ADAMTS13 activity <30%a) | P-value |
---|---|---|---|---|
ISTH score | 3 (2, 4) | 3 (2, 5) | 5 (5, 7) | 0.01 |
ADAMTS13 activity | 46% (39, 79) | 24% (19, 54) | 15% (9, 25) | 0.002 |
Severity of disease | Â | Â | Â | Â |
LOD score, day 1 | 7 (4, 9) | 7 (6, 10) | 13 (7, 14) | 0.02 |
SAPS II score, day 1 | 48 (38, 65) | 62 (47, 69) | 77 (51, 95) | 0.01 |
Systolic blood pressure, mmHg | 85 (80, 91) | 80 (67, 86) | 72 (67, 76) | 0.004 |
PaO/FiO2 | 240 (116, 300) | 140 (110, 245) | 95 (76, 127) | 0.02 |
Lactates, mmol/L | 2.6 (2.0, 5.6) | 3 (1.9, 6.3) | 6.4 (1.9, 16.5) | 0.06 |
IL-6 concentration, pg/mL | 78 (46, 126) | 318 (94, 1003) | 1,835 (500, 3,030) | 0.004 |
Outcome | Â | Â | Â | Â |
Need for mechanical ventilation | 19 (68) | 26 (79) | 10 (91) | 0.25 |
Persistent shock, day 3 | 10 (35.7) | 26 (79) | 11 (100) | 0.001 |
Need for RRT | 8 (28.6) | 10 (30.3) | 5 (45.3) | 0.24 |
Continuous hemofiltration | 2 (7.1) | 6 (18.2) | 4 (36.3) | 0.09 |
Dotrecogrin alpha activated | 2 (7.1) | 0 | 0 | 0.19 |
Stress dose steroids | 6 (21.4) | 6 (18.2) | 1 (9) | 0.64 |
Length of ICU stay | 5 (3, 13) | 5 (3, 13) | 6 (2, 15) | 0.95 |
ICU mortality | 6 (21.4) | 18 (54.5) | 5 (45.4) | 0.02 |
Hospital mortality | 28.6% | 71% | 75% | 0.007 |