The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation

Table 1 Comparison of biological parameters in patients as a function of the 30% median threshold of ADAMTS13 activity

Median (IQR) or number (%)	Patients with ADAMTS13 activity <30% (n = 36)	Patients with ADAMTS13 activity >30% (n = 36)	P-value
DIC	11 (31%)	8 (22%)	0.59
ISTH score	3 (2, 5)	3 (1, 4)	0.58
Platelet count, day 1	61 (27, 199)	136 (29, 191)	0.47
Platelet count <65 G/L	17 (47.2%)	20 (56%)	0.05
ADAMTS13:Ag, ng/mL	457 (374, 496)	533 (413, 680)	0.15
Positive anti-ADAMTS13 IgG	3	4	NA
Anti-ADAMTS13 inhibitor	0	0	NA
VWF:Ag, %	492 (369, 642)	560 (402, 700)	0.42
IL-6, pg/mL	895 (330, 1843)	83 (43, 118)	0.0003

Values are expressed as median and IQR for continuous variables and as number and proportion for categorical variables. Continuous variables were compared using the non-parametric Mann–Whitney U-test. Categorical variables were compared using the χ² test. P <0.05 was considered significant. DIC, disseminated intravascular coagulation; ISTH: International Society for Thrombosis and Haemostasis; ADAMTS13, a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13; Ig, immunoglobulin; VWF:Ag, von Willebrand Factor antigen; NA, statistical test not performed.

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