Figure 3
From: Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences
Molecular mechanisms implicated in endotoxin tolerance. DAP12, DNAX activation protein of 12 kDa; IFNβ, interferon-beta; IL, interleukin; IKK, IκB kinase; IRAK, interleukin-1 receptor-associated kinase; IRF3, interferon regulatory transcription factor 3; ITAM, immunoreceptor tyrosine-based activation motif; JAK, Janus kinase; miRNA, microRNA; MMP, matrix metalloproteinase; MyD88, myeloid differentiation primary response gene 88; NF-κB, nuclear factor-kappa-B; SOCS3, suppressor of cytokine signaling proteins 3; STAT1, signal transducer and activator of transcription 1; sTREM1, soluble triggering receptor expressed on myeloid cells 1; SyK, Spleen tyrosine kinase; TBK1, TANK-binding kinase 1; TGF-β, transforming growth factor-beta; TLR4, Toll-like receptor 4; TNF-α, tumor necrosis factor-alpha; TRAF6, TNF receptor associated factor (TRAF) protein family 6; TREM1, triggering receptor expressed on myeloid cells 1; TRIF, TIR-domain-containing adapter-inducing interferon-β.