Plasma neutrophil gelatinase-associated lipocalin in acute kidney injury superimposed on chronic kidney disease after cardiac surgery: a multicenter prospective study

Doi, Kent; Urata, Masahiro; Katagiri, Daisuke; Inamori, Mikako; Murata, Seiichiro; Hisagi, Motoyuki; Ono, Minoru; Matsubara, Takehiro; Ishii, Takeshi; Yahagi, Naoki; Nangaku, Masaomi; Noiri, Eisei

doi:10.1186/cc13104

Critical Care

Table 4 ROC analysis of plasma NGAL in non-CKD and CKD patients

From: Plasma neutrophil gelatinase-associated lipocalin in acute kidney injury superimposed on chronic kidney disease after cardiac surgery: a multicenter prospective study

Non-CKD	AUC-ROC	Cutoff (Youden)	Sensitivity (Youden)	Specificity (Youden)	Cutoff (95% sensitivity)	Specificity (95% sensitivity)	Cutoff (95% specificity)	Sensitivity (95% specificity)
(n = 78)	(95% CI)	(ng/ml)			(ng/ml)		(ng/ml)
pre	0.69	73	65%	75%	52	33%	298	15%
pre	(0.55 to 0.81)	73	65%	75%	52	33%	298	15%
0 h	0.76	102	65%	90%	49	33%	147	23%
0 h	(0.60 to 0.87)	102	65%	90%	49	33%	147	23%
2 h	0.67	142	45%	90%	48	19%	220	13%
2 h	(0.50 to 0.80)	142	45%	90%	48	19%	220	13%
4 h	0.76	72	90%	60%	49	28%	226	15%
4 h	(0.60 to 0.86)	72	90%	60%	49	28%	226	15%
12 h	0.73	90	70%	76%	48	26%	226	15%
12 h	(0.56 to 0.85)	90	70%	76%	48	26%	226	15%
24 h	0.73	91	75%	66%	47	14%	240	20%
24 h	(0.57 to 0.84)	91	75%	66%	47	14%	240	20%
36 h	0.63	113	55%	72%	44	10%	376	5%
36 h	(0.46 to 0.77)	113	55%	72%	44	10%	376	5%
60 h	0.62	124	55%	77%	35	1%	284	20%
60 h	(0.43 to 0.77)	124	55%	77%	35	1%	284	20%
CKD	AUC-ROC	Cutoff (Youden)	Sensitivity (Youden)	Specificity (Youden)	Cutoff (95% sensitivity)	Specificity (95% sensitivity)	Cutoff (95% specificity)	Sensitivity (95% specificity)
(n = 68)	(95% CI)	(ng/ml)			(ng/ml)		(ng/ml)
pre	0.71	472	33%	100%	68	23%	341	33%
pre	(0.56 to 0.82)	472	33%	100%	68	23%	341	33%
0 h	0.75	111	76%	63%	77	32%	233	30%
0 h	(0.61 to 0.85)	111	76%	63%	77	32%	233	30%
2 h	0.75	233	52%	94%	59	16%	241	44%
2 h	(0.61 to 0.85)	233	52%	94%	59	16%	241	44%
4 h	0.74	163	70%	69%	69	16%	286	40%
4 h	(0.60 to 0.84)	163	70%	69%	69	16%	286	40%
12 h	0.72	340	42%	97%	71	19%	322	42%
12 h	(0.58 to 0.83)	340	42%	97%	71	19%	322	42%
24 h	0.77	241	59%	85%	70	24%	363	43%
24 h	(0.63 to 0.87)	241	59%	85%	70	24%	363	43%
36 h	0.71	373	45%	94%	71	11%	379	44%
36 h	(0.56 to 0.82)	373	45%	94%	71	11%	379	44%
60 h	0.66	537	31%	97%	62	10%	432	31%
60 h	(0.51 to 0.78)	537	31%	97%	62	10%	432	31%

AUC-ROC, area under the curve operating characteristic curves; CI, confidence interval; CKD, chronic kidney disease; NGAL, neutrophil gelatinase-associated lipocalin.

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