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Table 4 ROC analysis of plasma NGAL in non-CKD and CKD patients

From: Plasma neutrophil gelatinase-associated lipocalin in acute kidney injury superimposed on chronic kidney disease after cardiac surgery: a multicenter prospective study

Non-CKD AUC-ROC Cutoff (Youden) Sensitivity (Youden) Specificity (Youden) Cutoff (95% sensitivity) Specificity (95% sensitivity) Cutoff (95% specificity) Sensitivity (95% specificity)
(n = 78) (95% CI) (ng/ml)    (ng/ml)   (ng/ml)  
pre 0.69 73 65% 75% 52 33% 298 15%
(0.55 to 0.81)
0 h 0.76 102 65% 90% 49 33% 147 23%
(0.60 to 0.87)
2 h 0.67 142 45% 90% 48 19% 220 13%
(0.50 to 0.80)
4 h 0.76 72 90% 60% 49 28% 226 15%
(0.60 to 0.86)
12 h 0.73 90 70% 76% 48 26% 226 15%
(0.56 to 0.85)
24 h 0.73 91 75% 66% 47 14% 240 20%
(0.57 to 0.84)
36 h 0.63 113 55% 72% 44 10% 376 5%
(0.46 to 0.77)
60 h 0.62 124 55% 77% 35 1% 284 20%
(0.43 to 0.77)
CKD AUC-ROC Cutoff (Youden) Sensitivity (Youden) Specificity (Youden) Cutoff (95% sensitivity) Specificity (95% sensitivity) Cutoff (95% specificity) Sensitivity (95% specificity)
(n = 68) (95% CI) (ng/ml)    (ng/ml)   (ng/ml)  
pre 0.71 472 33% 100% 68 23% 341 33%
(0.56 to 0.82)
0 h 0.75 111 76% 63% 77 32% 233 30%
(0.61 to 0.85)
2 h 0.75 233 52% 94% 59 16% 241 44%
(0.61 to 0.85)
4 h 0.74 163 70% 69% 69 16% 286 40%
(0.60 to 0.84)
12 h 0.72 340 42% 97% 71 19% 322 42%
(0.58 to 0.83)
24 h 0.77 241 59% 85% 70 24% 363 43%
(0.63 to 0.87)
36 h 0.71 373 45% 94% 71 11% 379 44%
(0.56 to 0.82)
60 h 0.66 537 31% 97% 62 10% 432 31%
(0.51 to 0.78)
  1. AUC-ROC, area under the curve operating characteristic curves; CI, confidence interval; CKD, chronic kidney disease; NGAL, neutrophil gelatinase-associated lipocalin.