Plasma neutrophil gelatinase-associated lipocalin in acute kidney injury superimposed on chronic kidney disease after cardiac surgery: a multicenter prospective study

Table 3 ROC analysis of plasma NGAL for dialysis requiring AKI

	Non-dialysis requiring AKI	Dialysis requiring AKI	AUC-ROC	Cutoff (Youden)	Sensitivity (Youden)	Specificity (Youden)	Cutoff (95% sensitivity)	Specificity (95% sensitivity)	Cutoff (95% specificity)	Sensitivity (95% specificity)
	(n = 44)	(n = 9)	(95% CI)	(ng/ml)			(ng/ml)		(ng/ml)
pre	122.5 (71.3 to 241.5)	482.0 (178.4 to 531.0)#	0.77	472	67%	89%	75	30%	785	11%
pre	122.5 (71.3 to 241.5)	482.0 (178.4 to 531.0)#	(0.55 to 0.90)	472	67%	89%	75	30%	785	11%
0 h	125.0 (90.0 to 187.8)	162.0 (121.0 to 272.0)	0.66	254	44%	89%	61	5%	469	0%
0 h	125.0 (90.0 to 187.8)	162.0 (121.0 to 272.0)	(0.44 to 0.83)	254	44%	89%	61	5%	469	0%
2 h	143.0 (89.7 to 238.8)	268.0 (171.0 to 419.0)#	0.75	170	89%	61%	89	23%	861	0%
2 h	143.0 (89.7 to 238.8)	268.0 (171.0 to 419.0)#	(0.54 to 0.88)	170	89%	61%	89	23%	861	0%
4 h	152.0 (92.9 to 228.8)	383.0 (235.0 to 619.5)#	0.81	220	89%	75%	100	27%	608	28%

AKI, acute kidney injury; AUC-ROC, area under the curve operating characteristic curves; CI, confidence interval; NGAL, neutrophil gelatinase-associated lipocalin.

ISSN: 1364-8535