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Table 1 Patient characteristics and clinical outcomes

From: Plasma neutrophil gelatinase-associated lipocalin in acute kidney injury superimposed on chronic kidney disease after cardiac surgery: a multicenter prospective study

  Non-CKD, Non-AKI Non-CKD, AKI CKD, Non-AKI CKD, AKI P- value
  (n = 58) (n = 20) (n = 35) (n = 33)
Age (y.o.) 67.5 (57.8 to 74.0) 64.5 (53.3 to 73.0) 74.0 (69.0 to 79.0) 69.0 (65.5 to 76.0) 0.0005
Male, n (%) 36 (62.1%) 16 (80.0%) 23 (65.7%) 17 (51.5%) 0.2
Diabetes, n (%) 24 (41.4%) 8 (40.0%) 15 (42.9%) 12 (36.4%) 0.95
Hypertension, n (%) 34 (58.6%) 15 (75.0%) 24 (68.6%) 22 (66.7%) 0.54
Preoperative      
Serum Cre (mg/dl) 0.75 (0.61 to 0.83) 0.76 (0.67 to 0.89) 1.13 (1.01 to 1.38) 1.39 (1.01 to 1.96) <0.0001
eGFR (ml/min/1.73 m2) 75.0 (67.2 to 82.1) 71.8 (64.1 to 83.6) 48.5 (35.3 to 53.4) 36.7 (26.1 to 53.0) <0.0001
Plasma NGAL (ng/ml) 61.0 (42.2 to 2.4) 75.5 (61.0 to 121.0) 120.0 (66.7 to 224.0) 209.0 (106.5 to 492.0) <0.0001
Operation      
Operation time (minutes) 296 (259 to 358) 330 (280 to 478) 304 (257 to 362) 355 (289 to 420) 0.064
OPCAB, n (%) 11 (19.0%) 5 (25.0%) 10 (28.6%) 6 (18.2%) 0.67
CPB, n (%) 47 (81.0%) 15 (75.0%) 25 (71.4%) 27 (81.8) 0.67
CPB time (minutes) 151 (119 to 204) 168 (132 to 286) 149 (115 to 195) 170 (110 to 228) 0.4
Valve surgery, n (%) 17 (29.3%) 7 (35.0%) 15 (42.9%) 12 (36.4%) 0.62
CABG surgery, n (%) 7 (12.1%) 1 (5.0%) 1 (2.9%) 5 (15.2%) 0.27
Valve + CABG, n (%) 7 (12.1%) 4 (20.0%) 5 (14.3%) 5 (15.2%) 0.86
Aortic graft replacement, n (%) 12 (20.7%) 3 (15.0%) 2 (5.7%) 1 (3.0%) 0.05
Other, n (%) 4 (6.9%) 0 (0.0%) 2 (5.7%) 4 (12.1%) 0.48
Postoperative      
Body weight gain (kg) 1.95 (0.77 to 3.30) 2.96 (1.33 to 4.73) 2.04 (1.07 to 3.93) 2.45 (0.64 to 3.88) 0.66
Need for RRT, n (%) 0 (0.0%) 2 (10.0%) 0 (0.0%) 7 (21.2%) 0.0001
ICU stay (day) 3 (2 to 4) 4 (2 to 10) 3 (2 to 4) 4 (2 to 10) 0.0077
  1. CABG, coronary artery bypass grafting; CKD, chronic kidney disease; CPB, cardiopulmonary bypass; OPCAB, off-pump coronary artery bypass grafting; RRT, renal replacement therapy.